Thiago Carvalho @cyrilpedia@social.cleverlibre.org

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Plan S re-fashioned as Plan U? https://www.nature.com/articles/d41586-023-03342-6

They call for a scholar-led system and articles available from the outset. In this respect it looks familiar ;-) https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3000273

I note this "seems a recognition that the first version of Plan S was going in an undesirable direction: its vision of open access has been delivered through business models which are highly inequitable”.

How peer review is paid for is TBD tho. And we mustn't forget other checks https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002234

“the [Gaza] health ministry’s figures from previous conflicts have been reliable, according to the UN and human-rights organisations, which have scrutinised them, and come up with their own estimates"

https://economist.com/interactive/the-economist-explains/2023/10/30/how-many-people-have-died-in-gaza

Daja Schichler, Antonia Konle, Brooke Morriswood @TIR_scienceblog and colleagues discover that entry of surface bound cargo in the trypanosome flagellar pocket is dependent on the hook protein TbSmee1 and clathrin-mediated endocytosis.
https://journals.biologists.com/jcs/article/136/20/jcs261548/334169/Characterisation-of-TbSmee1-suggests-endocytosis
Images showing that TbSmee1 is associated with the tip of the elongating new FAZ in replicating cells.

"A poet is the most unpoetical of anything in existence; because he has no identity — he is continually informing — and filling some other body."
Letter to Richard Woodhouse

British Poet John Keats was born #OTD in 1795. He was a romantic lyric poet who devoted his short life to the perfection of a poetry marked by vivid imagery, great sensuous appeal, and an attempt to express a philosophy through classical legend. via @Britannica

John Keats at PG:
https://www.gutenberg.org/ebooks/author/935

#books #poetry

@cyrilpedia
https://www.lemonde.fr/sciences/article/2022/01/15/en-disant-que-neandertal-etait-comme-nous-on-l-a-limite-a-nous_6109643_1650684.html

@tg9541 There are vague references to a 2020 study then this "Grodstein’s study, published earlier this year, made a notable discovery. While signs of vascular disease in the brain appeared to have decreased over time, the extent of the distinctive markers of Alzheimer’s in the brain stayed the same. This led the team to hypothesise that “any decrease in clinical Alzheimer’s dementia might be due in part to better cardiovascular health and in part to increased resilience to [the causes of] Alzheimer’s”, such as amyloid plaque, rather than to a decrease in Alzheimer’s pathology itself." which I think refers to this

https://jamanetwork.com/journals/jamaneurology/article-abstract/2801809

Interesting study of the performance of phylogenetic models for gene expression evolution, although they seem to have only investigated single-optimum OU models, which IMO limits conclusions on datasets with orthologs and paralogs. (Indeed they find poor performance for our 2016 dataset testing the ortholog conjucture.)
https://www.biorxiv.org/content/10.1101/2023.02.09.527893v2
#phylogeny #GeneExpression #MolecularEvolution #bioinformatics #phylogenetics

We've received a LOT of questions about how male spiders jettisoning their dicks could possibly improve their reproductive chances. Male genitalia isn't our specialty, and there's several reasons. Some of the reasons relate to vaginas so we'll answer your questions anyway.
https://masto.ai/@vagina_museum/111324292742285240

An ionic liquid-assisted sample preparation method for sensitive integral-membrane proteome analysis https://www.sciencedirect.com/science/article/pii/S0003269723003147?via%3Dihub

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#proteomics #prot-paper

Multi-pass, single-molecule nanopore reading of long protein strands with single-amino acid sensitivity https://www.biorxiv.org/content/10.1101/2023.10.19.563182v1.full.pdf+html

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#proteomics #prot-preprint

'AI-enabled drug discovery has yet to prove itself in the clinic. And on top of that, companies have to worry about intellectual property — regarding not only the drugs but also the discovery methods. “Everybody patents molecules,” says Alex Aliper, the president of Insilico Medicine, headquartered in New York City and Hong Kong. “For algorithms, it’s a choice.”

https://www.nature.com/articles/s41587-023-02029-7