Thiago Carvalho @cyrilpedia@social.cleverlibre.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
Thiago Carvalho
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Introduction time! I am Bram van Dijk, a computational biologist. 🦠💻
With biology drowning in cool data, I try to integrate our knowledge into models to generate new hypotheses. I do this by building simulations of microbial ecosystems (see movie below), with which I experiment. I like to refer to these systems as "Virtual Laboratories". By studying these, our initially flawed intuition can be turned into a system-level understanding of biology.
#introduction 
www.bramvandijk.com
"David Lynch as John Ford."
'nuff said
The Bear gets my vote for best new show of the year:
"The story of Carmy Berzatto, a celebrated chef who returns home to save the family business after the suicide of his brother, The Bear arrives at a gallop and never lets up. There’s obsession. There’s chaos. There is an episode delivered in a single breathless shot."
(Most disappointing was seeing the Jeff Bridges & John Lithgow stuck with writing worthy of a straight-to-video Putin-produced Steven Seagal film).
Thiago Carvalho
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🎄Recap @Nature #Clinicaloncology #Clinicalreviews current evidence for chronic immune toxicities #COVID19 & the long-term implications of these effects for patients receiving #Immunecheckpointinhibitors
📌https://www.nature.com/articles/s41571-022-00600-w
📌 https://www.nature.com/articles/s41591-021-01643-9
📌 https://www.nature.com/articles/s41590-022-01291-2
📌 https://jhoonline.biomedcentral.com/articles/10.1186/s13045-022-01325-0
📌 https://www.sciencedirect.com/science/article/abs/pii/S001430572200475X
📌 https://www.nature.com/articles/s43018-022-00418-6
📌https://www.nature.com/articles/s41571-019-0218-0
📌 https://www.nature.com/articles/s41568-022-00491-0
📌https://www.nature.com/articles/s41573-021-00259-5
📌https://www.nature.com/articles/s41571-022-00600-w
'In recent years, the vast archaeological park of Pompeii, a city buried alive by the eruption of Vesuvius in A.D. 79, has turned to high-tech options to maintain its excavated ruins. A surveillance drone makes a monthly flight over the site’s roughly 10,000 exhumed rooms. Artificial intelligence programs analyze aerial images for new cracks, fallen stones and other signs of erosion. But to prevent the third of the park that remains hidden under pumice and meters of earth from becoming overgrown with thorn bushes, wild hedges and trees, Pompeii has found a more appropriately ancient, and inexpensive, solution in hungry sheep.'
https://www.nytimes.com/2022/12/22/world/europe/pompeii-sheep-mount-vesuvius.html
Thiago Carvalho
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Admittedly, these days #mastodons have a very special place in our hearts😉 🥰, so this new research really speaks to us! The oldest #DNA ever recovered, from permafrost in Greenland, has revealed that the elephant-like creatures roamed northern #Greenland 2 million years ago. Now a barren polar desert, the area apparently used to be a lush landscape of trees & home to a diverse flora & fauna. 🤗 *Go mastodons, go!* 🐘 😉 https://nature.com/articles/d41586-022-04377-x
Thiago Carvalho
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New work from the lab out in Cell today, by En Yang and colleagues:
A brainstem integrator for self-location memory and positional homeostasis in zebrafish
"Cancer and aging are accompanied by stereotyped changes to the epigenetic landscape, including progressive loss of DNA methylation over gene-poor genomic regions (1, 2). Global hypomethylation arises in cells that have undergone many divisions, likely owing to imperfect maintenance. Evidence suggests that global hypomethylation represents a “mitotic clock” that counts divisions in somatic cells and functions to restrain aging cells and limit malignant progression."
Thiago Carvalho
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Algorithm Warfare: How Elon Musk uses Twitter to control brains. Mastodon is the only way https://georgelakoff.substack.com/p/algorithm-warfare-how-elon-musk-uses
Thiago Carvalho
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I forgot to post here that my article on #RNA as the molecule of the future was publish @DavidsonOnline in the begining of the month in Hebrew https://davidson.weizmann.ac.il/online/sciencepanorama/%D7%9E%D7%95%D7%9C%D7%A7%D7%95%D7%9C%D7%AA-%D7%94%D7%A2%D7%AA%D7%99%D7%93
It was now also published in Arabic
Thiago Carvalho
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#SocialMedia #Twitter #Musk #FreeSpeech: "In the middle of a workday, Sasha Solomon, a 34-year-old software engineer in Portland, Ore., put her French bulldog, Bosworth, on a leash and walked down a leafy street to a favorite coffee shop.
It seemed like an ordinary November afternoon, or as ordinary as it could be for someone working at Twitter under its mercurial new owner, Elon Musk. Ms. Solomon ordered a latte for herself and a drip coffee with cream for her husband. Then she and Bosworth headed back home.
Sitting at her computer on her living room couch, she tried to check the latest messages on Slack, only to find her account was locked. She then pulled up her work email account, or tried to. Also locked. She logged onto her personal email account and saw something in her inbox from a human resources executive at Twitter.
“Your recent behavior has violated company policy,” the email said, according to Ms. Solomon. She turned to her husband and said, as she recalled in a recent interview, “I guess I don’t work here anymore.”
With that, Ms. Solomon had become part of a small number of media industry employees who lost their jobs this year after using Twitter to take on the institutions where they worked. In Ms. Solomon’s case, she directly challenged her boss in a series of tweets. She said she is not sure whether those tweets caused her to lose her job, or if she was just one of the roughly 3,700 Twitter employees who got the ax in layoffs that began soon after Mr. Musk took ownership of the company in October."
https://www.nytimes.com/2022/12/23/style/twitter-elon-musk-sasha-solomon.html
Thiago Carvalho
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Look! @JoyceCarolOates has joined the Fediverse.
"To their Indigenous descendants, the stories we tell about these First Peoples of the Americas are highly relevant for additional reasons. Their deep ties and claims to the lands have often been ignored or expunged by governments, media and corporations across North and South America in order to make room for narratives that are more palatable, exciting or convenient to certain non-Native groups. The historical exclusion of Indigenous peoples from making decisions about research on their own ancestors and lands has caused significant harms to Native communities and individuals; when Native scientists and community members are full participants in the research process, the stories that emerge are not only more respectful but also more accurate."
https://aeon.co/essays/the-first-americans-a-story-of-wonderful-uncertain-science
'An alternative to gene therapy is enhancing the enzymatic activity through small molecules, an approach pursued by Bial, based in Portugal, which is conducting phase 2 trials of LTI-291, an activator of glucocerebrosidase acquired from Lysosomal Therapeutics.'
Thiago Carvalho
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For the holiday, a thread on how to befriend crows.
--
Befriending crows is a wonderful thing.
I have many crow friends at home and at work. They bring joy at unexpected moments and can rescue a miserable day even without shaking down the dust of snow that Robert Frost described.
This thread is an updated version of one I posted at the bird site in July 2019.
#birding #birdwatching #birds #urbanbirding #crows #corvids #crow #corvid #crowfriends
Thiago Carvalho
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Important thread from Dr. Gwen Randolph at WUSTL on her efforts to support women and fight misogyny from the inside: https://twitter.com/gwenrandolph_/status/1606270605149368320?s=12&t=PrXM8cP9ziV_QI8jht2CYg
Thiago Carvalho
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Henrietta Lacks is about to get recognition despite the fact that it comes after decades of silence. Her sacrifice wasn’t voluntary but the entire world owes her regardless.
#blackfriday #blackmastadon #blackjoy #science #medicine
https://www.theguardian.com/us-news/2022/dec/21/henrietta-lacks-statue-replaces-robert-e-lee-monument-virginia
Thiago Carvalho
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NEW: Elon Musk sent a Signal message ordering his staff to aid in the Twitter Files: "please give Bari [Weiss] full access to everything at Twitter. No limits at all.”
That triggered a frenzy inside Twitter, which was under a decade-old FTC order. IT staff refused to onboard Weiss, worried Twitter would be breaking the law.
Days later, two executives were fired.
"These guys did amazing damage,” a former employee told me of the Musk subordinates running the company.
https://www.washingtonpost.com/technology/2022/12/24/elon-musk-twitter-meltdown-tesla/
Thiago Carvalho
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RT @GwenRandolph_
Today is the opening day for the movie Women Talking. I cannot find a venue yet. Searches led me to this cancelled university screening for Dec 1. It is not hard to see “CANCELLED: Women Talking” as appropriate signage @WUSTL, for everything we have learned, seen here this month
Thiago Carvalho
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Our faculty of Maths & Computer Science at TU/e @TUEindhoven is recruiting 24 (!) new faculty - open rank. I would _love_ to welcome you as a new colleague! #hiring #tenuretrack #faculty #jobs #academicjobs #newpi https://www.tue.nl/en/working-at-tue/scientific-staff/ready-for-the-next-step-in-your-academic-career/?utm_source=linkedin&utm_medium=post&utm_campaign=teaser+broad+hire&utm_id=24+positions+M%26CS
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
