Thiago Carvalho @cyrilpedia@social.cleverlibre.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
Thiago Carvalho
boosted
@cyrilpedia I love this section: "How did ‘endemic’ — the term used in infectious disease to describe our relentless struggle in the relationship with our greatest scourges of HIV, tuberculosis and malaria — come to be re-appropriated to mean some form of victory over COVID-19? If we now meet the COVID challenge poorly and throw in the towel, historians may puzzle over our ineptitude for centuries to come."
Thiago Carvalho
boosted
"...we now again face segregation into rival tribes: the short attention spans, COVID-19 revisionism and ‘move along, there’s nothing to see here’ attitude of our global leaders threatens the laser focus that the scientists will need if we are to avoid endemic bedding-in of massively elevated mortality along with a lasting worldwide burden of disability imposed by more than 150 million cases of long COVID. "
Brilliant stuff from Daniel Altmann. #COVID H/T @cyrilpedia
"All mammals have platelets, which are necessary for survival because they arrest bleeding (haemostasis). No other order has platelets, even though the problem of bleeding exists. A solution to the enigma of why only mammals have platelets was recently proposed, linking the origin of the platelet in an egg-laying animal, which initially did not have platelets, to the evolution of the eutherian (haemochorial) placenta found in all mammals apart from monotremes and marsupials"
"The SARS-CoV-2 immunology dataset rapidly overtook our knowledge of most other human pathogens that had been studied for decades. Yet, lest we sink into self-congratulatory immunological hubris, there are huge and self-evident caveats to our pride in these achievements."
'Between 1995 and 2016, the number of independent bookshop members in the BA dropped from 1,894 to 867 as the industry faced stiff competition from Amazon and financial pressures from business rate hikes. However, with the ongoing resurgence that figure reached 1,072 in 2022, a net increase of 45 on the tally of 1,027 for 2021.'
"To extend the current knowledge on maternal microchimerism functions to their postnatal immune roles, we implemented an approach to deplete maternal cells in the neonates by diphtheria toxin (DT) injection and compared the spleens’ immune profiles of the 2-week-old pups with intact and depleted maternal cells by mass cytometry immunophenotyping."
Thiago Carvalho
boosted
It's great to see the Cdc42 biosensor that we optimized has been used to detect active Cdc42 near invadopodia. Find all of the details in the publication coordinated by Rafael Garcia-Mata : https://rupress.org/jcb/article/22
"he mutational signatures attributed to APOBEC3 cytidine deaminases are pervasive in human cancers. However, data linking individual APOBEC3 proteins to cancer mutagenesis in vivo are limited. Here, we showed that transgenic expression of human APOBEC3G promotes mutagenesis, genomic instability, and kataegis, leading to shorter survival in a murine bladder cancer model."
'Gene duplication and diversification allow hosts to mutate otherwise essential genes, whereas changes in transcriptional regulation can selectively activate genes should their constitutive expression be detrimental. To counter mutational tolerance, it has been suggested that viruses target essential genes as host cofactors, because the genes are less prone to variability'
#Virology #HostPathogen #RNASplicing
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3001934
Thiago Carvalho
boosted
A List of Things People Blamed on Jazz
🧵
The latest episode of the #EMBOPodcast is out.
I spoke with Steve Quake, the new head of science at CZI (taking over from @CoriBargmann) about his career, #OpenScience, cell atlases, imaging, @ReviewCommons and lots more.
You can listen to it at the link below or on any podcast app.
https://www.embo.org/podcasts/the-biologists-were-pretty-darn-good-with-their-microscopes/
Thiago Carvalho
boosted
“Forget inspiration. Habit is more dependable. Habit will sustain you whether you’re inspired or not. Habit will help you finish and polish your stories. Inspiration won’t. Habit is persistence in practice.” — Octavia Butler
#writinglife #writingcommunity #writerscommunity #creativity #inspiration #writing #storytelling #screenwriting #writingtips #art #OctaviaButler
Thiago Carvalho
boosted
The deadline to apply for a #funded early-career researcher place at our Workshop on #gut #physiology has been extended. New deadline: 15 February 2023.
'Inside Out: New Frontiers in the Comparative Physiology of the Vertebrate Gut' is organised by Carol Bucking and Chris Wood and takes place in June 2023. Find out more and apply here:
https://www.biologists.com/workshops/jun-2023/
#BiologistsWorkshops #Co_Biologists #ECRs #Science #Biology #AcademicMastodon
"Wellcome, Britain’s largest charity, has pledged to almost double spending on science and health to £16bn over the next 10 years, even if it has to spend down some of its endowment."
https://www.ft.com/content/6a5d5e3d-681b-4dc3-8081-f4248cc7e47a
"But while some parasitic species are getting a boost from climate change, they may be the exception rather than the rule. According to a groundbreaking study published Monday in the Proceedings of the National Academy of Sciences that analyzed 85 parasitic species, the majority suffered population declines over 140 years, on par with some of the most threatened wildlife species — or worse."
Thiago Carvalho
boosted
A surprising finding from the Klaembt lab: myelination in adult #Drosophila: Rey et al. (2023). Glial-dependent clustering of voltage-gated ion channels in Drosophila precedes myelin formation. bioRxiv, 2023.01.09.523229 -- https://doi.org/10.1101/2023.01.09.523229
Thiago Carvalho
boosted
We are delighted to kick off our 2023 SciArt profiles by featuring Mol Mir @molecularmirror, Science Visualization Specialist at Stowers Institute . To find out more about Mol’s journey in the science and art world, and to see some stunning artwork, check out their profile here:
https://thenode.biologists.com/sciart-profile-mol-mir/science-art/
Mixed results for Molnupiravir, Butler et al, Lancet:
"Molnupiravir did not reduce hospitalisations or deaths in a community-based vaccinated adult population with COVID-19 who were at increased risk of an adverse outcome, either overall or in any patient subgroups. However, molnupiravir was associated with reduced time to recovery overall and for key individual symptoms, reduced health-care seeking for some primary care services, and reduced viral load."
#Covid19 #Coronavirus #COVID #SarsCov2
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(22)02597-1/fulltext
Thiago Carvalho
boosted
As the new scope takes shape, it's a good time to remind you: last week to apply to our postdoc position! neurocytolab.org/positions-2/
Thiago Carvalho
boosted
Dorsal aorta polarization and haematopoietic stem cell emergence
In their Review, Laurent Yvernogeau, Giovanna Dainese and Thierry Jaffredo discuss dorsal aorta formation and its role in generating haematopoietic stem cells.
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
