Thiago Carvalho @cyrilpedia@social.cleverlibre.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
"The retaliation I faced from the A.G.U. and Oak Ridge ultimately highlights a disappointing reality: that established scientific institutions will not even support scientists interrupting a meeting for the climate. I’m all for decorum, but not when it will cost us the Earth."
Thiago Carvalho
boosted
Update: I was fired. I loved working at ORNL's Climate Change Science Institute and am devastated, but am also more determined and hopeful than ever. We have incredible power to affect change together.🌱
I still plan to continue with both research & activism, to the extent possible.
To my wonderful colleagues: My temporary affiliation is LSCE. Please use my personal rather than my work email, which I no longer have access to. Thank you for all of the support so far ♥️
https://www.nytimes.com/2023/01/10/opinion/scientist-fired-climate-change-activism.html
Thiago Carvalho
boosted
The latest episode of the #EMBOPodcast is out.
I spoke with Steve Quake, the new head of science at CZI (taking over from @CoriBargmann) about his career, #OpenScience, cell atlases, imaging, @ReviewCommons and lots more.
You can listen to it at the link below or on any podcast app.
https://www.embo.org/podcasts/the-biologists-were-pretty-darn-good-with-their-microscopes/
'La Nobel Carolyn Bertozzi: “En Qatar no merezco estar viva por ser lesbiana, pero les encantarán mis fármacos contra el cáncer”
"To better understand the differential outcomes between the young and the elderly following brain injury, we performed bulk RNA-seq on young and aged meninges 1.5 months after TBI. Notably, we found that aging alone induced upregulation of meningeal genes involved in antibody production by B cells and type I IFN signaling."
'Joe Biden condemned violent riots in Brazil as the White House faced calls from Congress to expel Jair Bolsonaro, the Latin American country’s former president, from the US, where he has been staying since leaving office.'
https://www.ft.com/content/5d27d6ac-9658-43ad-91fc-fe9820db21cd
Thiago Carvalho
boosted
The Social Code—Deciphering the Genetic Basis of Hymenopteran Social Behavior. @Amy_L_Toth @sanrehan @WaspWoman @Wyatt1Chris and @EmelineFavreau set out to uncover early genetic changes on the path to sociality. https://buff.ly/3k8cXL7
Thiago Carvalho
boosted
If you're a group leader interested in writing an 'In preprints' article for @Dev_journal about #preprint(s) you think the #devbio and stem cell community would find interesting, please get in touch!
You can see the growing collection of #preprintCuration articles here: https://journals.biologists.com/dev/collection/7815/In-preprints
Thiago Carvalho
boosted
Picking up on some of the BIG IDEAS in brain research, which was wonderfully chaotic when we last discussed in December under the hashtag #BrainIdeasCountdown, e.g. https://neuromatch.social/@NicoleCRust/109557289393362842
Here's an attempt to fill in some blanks, and let's flip the hashtag: #BigBrainIdeas. I'll focus on the notion that there are facts, ideas and then there are "Big Ideas" and I'll focus on the last one. Please join in!
I'd argue that one of the most influential Big Ideas about the brain in the latter half of the 20th century is the is the notion that:
The neocortex of the brain is made up of a generic functional element that is repeated again and again and from this repetition, all of cortical function emerges
I'm talking about the cortical column, first described by Vernon Mountcastle in 1957. The unit contains ~10K neurons and humans have ~25 million of them. The rapid evolution of humans is proposed to have followed from a rapid expansion of cortex that happened because it has this repetitive crystalline structure. The gist behind the "functional" bit is that each unit always does the same generic computation, and the different functions of different brain areas result from the different inputs that these units receive. @TrackingActions very nicely summarizes the ideas here: https://www.nature.com/articles/s41583-022-00658-6
So what does this generic functional unit do? Proposals vary. One idea, also reflected in deep convolutional neural networks, is that it does two(ish) things: selectivity and invariance, stacked repetitively to support things like recognizing objects. Other proposals suggest that the brain is a prediction machine and each unit contributes a little bit to those predictions in a manner that relies not just on feedforward connectivity, but also feedback. Some proposals suggest that the function of the unit varies along a gradient as a consequence of biophysical properties like receptor expression: https://www.nature.com/articles/s41583-020-0262-x.
Among brain researchers, this Big Idea is polarizing - obvious to some and misguided to others. Where are you in terms of your 'buy in' with this big idea?
Thiago Carvalho
boosted
Job: 2 PhDs trophic ecology of marine mammals - UK
2 #PhD projects on the trophic #ecology of #MarineMammals Univ #Exeter, #UK with @luishuckstadt
1) Understanding the effects of rapid #EnvironmentalChange on the ecology of a key Southern Ocean predator, the #Antarctic fur seal
2) Monitor the status of coastal ecosystems in South West England: from #RemoteSensing to marine top predators
https://www.luishuckstadt.com/blog/two-fully-funded-phd-projects-in-our-lab-please-share-widely
Thiago Carvalho
boosted
RT @RealTimeCOVID19
NIH study: a history of MIS-C is NOT associated with increased risk of serious adverse reactions following COVID-19 vaccination #pediatrics #vaccinesafety https://twitter.com/nih_nhlbi/status/1610328538569129985
Thiago Carvalho
boosted
New article! Read Titers of antibodies against ancestral SARS-CoV-2 correlate with levels of neutralizing antibodies to multiple variants https://www.nature.com/articles/s41541-022-00586-7?utm_source=dlvr.it&utm_medium=mastodon in npj Vaccines
"The results demonstrate that the hamster model reliably phenocopies indicators of a dysregulated alveolar regeneration of COVID-19 patients. The study provides a suitable translational model for future research on the pathomechanims of PASC and testing of prophylactic and therapeutical approaches."
"Our results suggest that, in a cellular context, Fab glycans inhibit IgG–hFcRn interaction and thus negatively affect the transplacental transfer of IgG. As Fab-glycosylated Abs are frequently associated with autoimmune and malignant disorders and may be potentially harmful, this might encompass a regulatory mechanism, limiting the half-life and transport of such Abs."
Thiago Carvalho
boosted
We've had some great long-form #interviews with active research scientists on topics like #preprint distribution, #openscience and science #publishing on The Commons - the Review Commons #blog - including:
Mark Hanson https://www.reviewcommons.org/blog/models-oddballs-and-preprints-a-conversation-with-mark-hanson/
Caren Norden https://www.reviewcommons.org/blog/i-believe-in-the-peer-review-process-a-conversation-with-caren-norden/
Marco Trizzino https://www.reviewcommons.org/blog/i-think-review-commons-is-the-future-an-interview-with-review-commons-author-marco-trizzino/
Thiago Carvalho
boosted
Nice summary by Ken Zaret of our (@joadelas@twitter.com) recent work investigating the genomic mechanisms interpreting SHH morphogen signaling in the neural tube
Two ways to skin a new cell fate https://www.cell.com/developmental-cell/fulltext/S1534-5807(22)00846-2#.Y716CdxYzO8.twitter
Thiago Carvalho
boosted
Meet the first Black American to earn an evolutionary biology Ph.D.
https://sciencenews.org/article/first-black-american-evolutionary-biology-phd
Joseph L. Graves Jr. offers a memoir and more in ‘A Voice in the Wilderness’
'As E. B. White wrote in a collection of his own correspondence (edited by Dotty, who was his goddaughter), “A man who publishes his letters becomes a nudist—nothing shields him from the world’s gaze except his bare skin,” and if we know anything about Salinger it’s that he would not have liked that.'
https://www.newyorker.com/culture/comma-queen/the-editor-who-edited-salinger
"On 6 January 2021, Bolsonaro – now known as ‘Captain Fugitive’ by his disappointed supporters – tweeted that the invasion of the US Congress was small potatoes compared to what he would have in store for Brazil should he lose the elections in 2022. For once, he appears to have been telling the truth, since the mob in the Praça dos Três Poderes was much larger than the one in DC, and wreaked greater destruction on the physical infrastructure of the federal government."
https://www.lrb.co.uk/blog/2023/january/chronicle-of-a-coup-foretold
Thiago Carvalho
boosted
Yes, the explosive period of the #mpox outbreak has been quelled. But the global footprint of the virus is now bigger than it was before. And as attention on mpox wanes, cases could go undetected & unreported. https://www.statnews.com/2023/01/10/health-officials-fear-mpox-infections-will-go-undetected-unreported/
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
