Thiago Carvalho @cyrilpedia@social.cleverlibre.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
Antigen independent metabolic effects of CAR constructs:
"Here we show that CARs differing only in the scFv reprogram T-cell metabolism differently. Even in the absence of antigens, some CARs increase proliferation and nutrient uptake in T cells."
#immunology #Preprint #Immunotherapy #CARTcells
'Deadline to apply has been extended to 15 April for EMBO Lecture Course Venice Summer School: The future of evolutionary-developmental systems biology 21 – 25 August 2023 in Venice, Italy'
'Countries negotiating a crucial treaty on pandemics at the World Health Organization have so far struggled to agree key points including the basic definition of a pandemic, despite targeting a rapid timetable for a deal in 2024'
https://www.ft.com/content/cbfe34be-2b76-4bf5-82cd-396e8695569d
Paul Berg's obit in Science
"In the early 1970s, as the enzymology of DNA manipulation became available, Paul recognized that the DNA of SV40 and the DNA from bacteria or bacterial viruses could be joined to form hybrids or chimeric molecules—later known as recombinant molecules. The technology of making and manipulating such non-natural but extremely valuable molecules was called recombinant DNA technology."
Thiago Carvalho
boosted
'Here’s the bottom line from it: “Mild Cognitively Impaired participants treated with anti-Aβ drugs were projected to have a material regression toward brain volumes typical of Alzheimer’s dementia ∼8 months earlier than if they were untreated.” I would say that if someone wants to make the argument that this is of no consequence (or perhaps even beneficial?) that they should step right up and have a crack at it. I (and many others) will watch with great interest. On the other hand, if the way of dealing with these findings is to pretend that they don’t exist, that is really unacceptable.'
Thiago Carvalho
boosted
An organoid model for thyroid cancer (#Preprint).
Thiago Carvalho
boosted
In our eighteenth 'Transitions in development' #interview, Cross-Title Reviews Editor Daniel Routledge speaks to Jingli Cao about his #career path, his experience of becoming a group leader and his love for #astronomy
Thiago Carvalho
boosted
22 years after publication of the human genome, we're still counting the genes. Nice overview by Amaral et al:
The status of the human gene catalogue https://arxiv.org/abs/2303.13996v1 #Genomics #bioinformatics
Thiago Carvalho
boosted
Check out our interview with Brent Foster, one of the Node correspondents. We find out about Brent’s research, science writing & what he’ll be blogging about on the Node.
https://thenode.biologists.com/meet-our-the-node-correspondents-brent-foster/news/
You can read Brent’s first post here:
https://thenode.biologists.com/if-you-give-a-scientist-a-cuttlefish/research/
All of the posts from our correspondents will appear on our dedicated topic page: https://thenode.biologists.com/the-node-correspondents/
Thiago Carvalho
boosted
Thiago Carvalho
boosted
April 4, 2021, microbiologist Thomas Brock died #OTD at the age of 94. His discovery of thermophile bacteria at #Yellowstone in 1966 revolutionized biology & eventually allowed the development of tests for DNA & #COVID-19 🌋🦠
"Whether perturbations of any of these endosome-related processes can give rise to TLR7 gain-of-function and facilitate self-reactivity has not been investigated. Here, we show that a dysregulated endosomal compartment leads to unrestricted TLR7 signaling and human lupus."
#Preprint #Immunology #InnateImmunity #Lupus #TollLikeReceptor
"Understanding the mechanisms that maintain the endothelial barrier in the context of pathological stressors is the first step toward the development of new therapeutic approaches for retinopathies."
Thiago Carvalho
boosted
RT @ElizSMcKenna
In the April issue of @CD_AACR - a new review by @hamieh @JorgeMansilla_S Isabelle Rivière & @Michel_Sadelain @MSKCancerCenter: Programming CAR T Cell Tumor Recognition: Tuned Antigen Sensing and Logic Gating https://aacrjournals.org/cancerdiscovery/article/13/4/829/724992/Programming-CAR-T-Cell-Tumor-Recognition-Tuned #immunotherapy
Opportunity for pathogen genomics folks from Africa (African Union Member States):
"The program is open to National public health institutes (NPHIs) and National Reference Laboratories (NRLs) personnel who wish to gain experience in NGS sequencing or analyzing pathogen genomic sequence data. Applicants should have a minimum of BSc degree and be a citizen of the African Union Member States."
Thiago Carvalho
boosted
'Fungal epidemics in humans are infrequent, in part because human-to-human transmission of fungi is rare, and I am not aware of any involving zombielike creatures. It’s far more likely that the next pandemic will come from a virus. But the idea that climate change is making the emergence of new health threats more likely is solid. Could it cause a fungus ubiquitous in the environment to morph into a lethal pathogen in humans? It’s possible.'
https://www.nytimes.com/2023/04/02/opinion/the-last-of-us-fungus-climate-change.html
Thiago Carvalho
boosted
Thiago Carvalho
boosted
'Ben Barres Early Career Acceleration Awards. This is an investigator award for early career academic investigators, especially those who are new to the field of neurodegeneration. Awards are $1.2M in total costs over 4 years. Early career investigators will benefit from mentored support and resources of the CZI Neurodegeneration Challenge Network.'
https://chanzuckerberg.com/rfa/ben-barres-early-career-acceleration-awards/
Thiago Carvalho
boosted
RT @BrimacombeChris
Use caution when reusing ecological networks! Our new paper at @PLOSBiology shows that open species interaction networks are very structurally heterogenous, with those coming from different publications exhibiting the greatest heterogeneity. https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002068
'In 2025 we will be continuing our efforts to diversify our Workshop programme so that we are able to support a wider selection of research communities around the world.
We will be reserving one of our Workshops for an application from a Global South (GS) country to host an event overseas.'
https://www.biologists.com/workshops/propose-new-workshop/#global_south
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
