Thiago Carvalho @cyrilpedia@social.cleverlibre.org

“If you think we could be close to something potentially so dangerous,” I said to the researcher, “shouldn’t you warn people about what’s happening?” He was clearly grappling with the responsibility he faced but, like many in the field, seemed pulled along by the rapidity of progress.'

https://www.ft.com/content/03895dc4-a3b7-481e-95cc-336a524f2ac2

"These drugs (such as semaglutide, which is Ozempic/Rybelsus/Wegovy) are famous now because of the huge impact they’ve made in the obesity market, and the market is increasing every day. We’re going to have a lot more people taking these drugs, and we may find out a lot more about them in the process."

https://www.science.org/content/blog-post/ozempic-and-other-glp-1-drugs-more-people-realize

"In people with SARS-CoV-2 infection who were at risk of developing severe disease, compared with no treatment, nirmatrelvir was associated with a reduced risk of admission to hospital or death at 30 days in people who were not vaccinated, vaccinated, and had received a booster vaccine, and in those with a primary SARS-CoV-2 infection and reinfection."

#SARSCoV2 #covid19

https://www.bmj.com/content/381/bmj-2022-073312

Brexanolone is administered as an iv infusion over a 60 hour period (in a hospital setting).

As Pam Belluck of the NYT had noted in 2019, making an orally available form was the clear next step.

"A pill made with a similar molecule, which would be much more accessible and easier for patients, is showing promise in its clinical trials and would be submitted for approval in a couple of years if the results are good, according to Sage."

https://www.nytimes.com/2019/03/19/health/postpartum-depression-drug.html

The topic of my latest #NatureMedicine Clinical Pipeline column, zuranolone, represents an improvement in both safety & ease of administration over its on its predecessor, brexanolone (which was the first drug approved specifically for postpartum depression in 2019). The case for it in major depressive disorder is more complex.

https://www.nature.com/articles/d41591-023-00032-8

"Maps 6 & 9. The Origami Maps (Dresden, 1914-1918)

These maps, or objects, represent the sole known instance of an attempt at creativity by the Margrave. Like so many Europeans of his generation, von Willebrand was enthralled by Japanese art, and he developed a particular fascination with origami – a set of techniques with ancestral origins in Japan whose basic principles influenced the “folds of truth, folds of life and folds of beauty” ideas of German pedagogue Friedrich Fröbel.
Tragically, von Willebrand brought his newfound creativity to bear on the problems of cryptography – the Margrave was ever mindful of his duty to the Fatherland. von Willebrand’s work on the tactical applications of origami in the battlefield somehow managed to pique the interest of the Kaiser’s father, Frederick III, during his brief 99-day reign. When Frederick died, his relationship with the Margrave ultimately led his son Kaiser Wilhelm II to authorize a field test of the origami system during the Third Battle of Ypres. As a result, an entire German reconnaissance platoon was picked off one by one by a perplexed British sniper as they tried to fold paper while wearing full anti-gas gear."

#prints #Printmaking #cartography #handmade #artmastodon #artgallery #origami #origamiart

https://madalenaparreira.com/SPAM

'In the early pages of Good Girls, Hadley Freeman lists the 75 theories that doctors, therapists and outsiders developed for why she suffered anorexia as a teenager. First on the list: her birth by caesarean, which a psychiatrist claimed meant she would “always try to look for the easy way out”.

https://www.ft.com/content/e08ae8bd-69e0-4f99-ae28-537f9e178585

"De hecho, en los documentos que se conservan del Concilio de Elvira (Granada), a principios del siglo IV, ya hay constancia de la presencia de judíos en Hispania. Se trataba de inmigrantes que buscaban recursos de supervivencia en la costa mediterránea, fundamentalmente en Elche y Tarragona, pero también en grandes ciudades de la época como Mérida."

https://elpais.com/cultura/2023-04-13/sinagogas-cementerios-y-barrios-enteros-el-patrimonio-cultural-oculto-de-los-judios-en-espana.html

Deadline June 15.

"Applications must be submitted by a consortium composed of 4–6 higher education institutions from eligible countries in Africa and one higher education institution from the EU. The selected consortia will organise activities to implement the mobility of Master and Doctoral level students, trainees (students enrolled in a Bachelor, Master or PhD programme), and academic and administrative university staff within Africa."

https://international-partnerships.ec.europa.eu/news-and-events/news/global-gateway-european-commission-announces-funding-opportunity-academic-mobility-africa-2023-04-05_en

Single cell RNAseq atlas of the human bone marrow

https://elifesciences.org/articles/81656