Thiago Carvalho @cyrilpedia@social.cleverlibre.org

A reference framework to normalize human lymphocyte numbers in ageing.

'In this study, we analyze cross-sectional numbers of mainly T lymphocytes (CD3+, CD3+CD4+, and CD3+CD8+) and their subpopulations (naive and memory) from 673 healthy Dutch individuals ranging from infancy to adulthood (0–62 y). We fitted the data by a delayed exponential function and estimated parameters for each lymphocyte subset.'
#Immunology #Ageing

https://journals.aai.org/jimmunol/article-abstract/doi/10.4049/jimmunol.2200520/263658/Age-Dependent-Normalization-Functions-for-T?redirectedFrom=fulltext

'Our findings demonstrate that developmental bias in fly wings predicts evolvability and macroevolutionary trajectories on a much greater scale than previously appreciated but also suggest that causal explanations for such alignments may go beyond simple constraint hypotheses.'
#Evolution #EvoDevo

https://www.pnas.org/doi/10.1073/pnas.2211210120

This is definitely an area where it makes sense that AI could outperform humans.

'The new methodology is “remarkable”, says Dave Mauger, a computational RNA biologist who previously worked at Moderna in Cambridge, Massachusetts, a maker of mRNA vaccines. “The computational efficiency is really impressive and more sophisticated than anything that has come before.”

https://www.nature.com/articles/d41586-023-01487-y

Big thank you to #TheMicrobiologist for highlighting our recent work on a
biofilm-disrupting #bacteriophage. https://www.the-microbiologist.com/phage-delivers-double-whammy-against-biofilms/891.article

#Klebsiella #biofilm

Postdoctoral Research Scientist

https://jobrxiv.org/job/columbia-university-in-the-city-of-new-york-columbia-university-irving-medical-center-vagelos-college-of-physicians-and-surgeons-neurological-surgery-27778-postdoctoral-research-scientist/?feed_id=44364

#ScienceJobs #job
New York #UnitedStatesUS #Scientist
https://jobrxiv.org/job/columbia-university-in-the-city-of-new-york-columbia-university-irving-medical-center-vagelos-college-of-physicians-and-surgeons-neurological-surgery-27778-postdoctoral-research-scientist/?feed_id=44364

Jair Bolsonaro, who shared the 2020 Ig Nobel Medical Education Prize "for using the Covid-19 viral pandemic to teach the world that politicians can have a more immediate effect on life and death than scientists and doctors can", is in the news again. https://www.reuters.com/world/americas/brazil-police-raid-bolsonaros-home-part-covid-vaccine-probe-source-2023-05-03/

#scRNAseq of 18,900 pre-leukemic & leukemic cells reveals transformation of #Hematopoietic #StemCells into full-blown #AcuteMyeloidLeukemia, emphasizing the critical role of #RNAsplicing in the emergence & maintenance of #leukemia #PLOSBiology https://plos.io/3LOnfer

The Rap Guide To Consciousness

Yup, it exists. Baba Brinkman. "Let me show you how to be a good Bayesian ..."
https://www.youtube.com/watch?v=qV6Wc_f1Cgo

Our lab has started a weekly journal club covering classic papers in immunology. First up, Mosmann and Coffman use murine CD4+ T cell clones and establish the Th1/Th2 paradigm. Journal of Immunology in 1986.

"The derivation of two distinct types of Th cell clones raises the question of the total diversity of T cell phenotypes."

https://pubmed.ncbi.nlm.nih.gov/2419430/

#Immunology

Ainda o básico. Com importância em alturas epidémicas e na medicina do viajante. https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(23)00021-1/fulltext?dgcid=raven_jbs_aip_email

Etching on copper by @madparreira

#printmaking #art #print #printmaker #etching #handmade #prints #artgallery #artmastodon
https://madalenaparreira.com/Etchings

@vigji @vilim

Nice central complex you have in there 😜 – convergent evolution or shared descent? Any gene expression or developmental evidence for or against?

(And did Nick Strausfeld already contacted you? Or Frank Hirth and their MHB gene expression markers?)

#Drosophila #zebrafish #bumpology #neuroscience

"Before 2002, no in-depth information was available on human CoVs (HCoVs) and their zoonotic potential. The emergence of the first highly pathogenic HCoV in 2002, SARS-CoV-1, the subsequent epidemic MERS-CoV, and the pandemic SARS-CoV-2, opened “Pandora’s box” on CoVs." I remember my virology textbook (~1984) had a half-page on coronaviruses. We've come a long way, but not done yet.
Very interesting review from animal pathology perspective. #virology #coronaviruses

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10143937/

Explore emerging #Neurodevelopment #Genetics research with field leaders
@KeystoneSymp
Understanding #DevelopmentalDisorders in the Genomic Age, this June in Tarrytown. https://hubs.la/Q01LWPml0
#KSDevDisorders23

Nice that @genomeresearch highlights its #MastodonScience account on its homepage https://genome.cshlp.org/

FTC chair Lina Khan writes editorial on the task of regulating AI. #uspol #GiftLink (pls do not be alarmed by the unlocked_article_code argument in the URL to the New York Times) https://www.nytimes.com/2023/05/03/opinion/ai-lina-khan-ftc-technology.html?unlocked_article_code=IqOGnSrbDTwayRWF0aVGngJjzNHq8mza-YEtpW5Ii2XkJb4LPdS_dh02ymHfWbPolkv-cwKcuIOnAubcvI3IyZiYgBpLJ7yAxCliVKQ5Kl5qsk-BdGS5zXfIC962kP09-U4nsxIMZreHTLZXmgksWphIZ1raQu_xhirckOS6Cfz1m55ZWDLNDllNVPPbEOAxuZJZA-Y1JDM46bQwxG1ggVoKaBPJbzxE_tfaHxYdKYpcbCDlmcCrBdjxi8GkUHjRIhVcr7ekgX11_CyibZ1LgY-igQSBWs8EMscg8CGOBCctQSotFpcfKK6Kr-JYkzzf8a0zlK6f5ZIwK1NuszHVkwRr-xYJ&smid=nytcore-ios-share&referringSource=articleShare

Police in #Brazil seize cell phones of former President Bolsonaro and his wife as part of an investigation into whether the family forged false #COVID19 vaccination certificates for travel to the US. https://oglobo.globo.com/blogs/bela-megale/post/2023/05/pf-apreende-celulares-de-bolsonaro-e-michelle.ghtml