'To identify tumor-intrinsic drivers of resistance, we quantified in-vitro response to CD19-directed chimeric antigen receptor T-cells (CD19-CAR) and bispecific antibodies (BsAb) across 46 B-NHL cell lines and measured their proteomic profiles at baseline. Among the proteins associated with poor in-vitro response was Serpin B9, an endogenous granzyme B inhibitor.'
#CART #immunotherapy #Immunology #immunooncology #Preprint
https://www.biorxiv.org/content/10.1101/2023.06.26.546507v1?med=mas
Lukashenko was awarded his second Ig Nobel Prize (which he shared with the leaders of eight other countries) for using the Covid-19 viral pandemic to teach the world that politicians can have a more immediate effect on life and death than scientists and doctors can. https://improbable.com/ig/winners/#ig2020
"That's a long-winded way of explaining how I got from working on stress to being interested in the microbiome. The next 10 years were focused on taking advantage of advances in technologies, genetics and sequencing to parse the relationship between the microbiome and the brain and, more recently, on asking if we can translate it to humans."
- John Cryan
Os colegas do Montenegro
'Segundo o relatório, o partido “tem trabalhado para envenenar o discurso nacional com retórica racista, anti-LGBTQ+, anti-imigração e anticigana". Estou convicta de que os portugueses - os que não estão envenenados – não precisariam de que uma organização estrangeira viesse clarificar que é de cariz racista a retórica do Chega.'
'Daily oral orforglipron, a nonpeptide GLP-1 receptor agonist, was associated with weight reduction. Adverse events reported with orforglipron were similar to those with injectable GLP-1 receptor agonists.'
https://www.nejm.org/doi/full/10.1056/NEJMoa2302392?query=featured_home
'How has the tech sector got away with exceptionalism for so long? Whenever the harmful effects of a new technology emerge, the loudest clamour opposes regulation, arguing that it would strangle innovation and that the engineering is too complex for legislation.'
https://www.ft.com/content/c668bf20-40ea-4eb9-8910-ab63d213a63b
'Out of about 34,000 Ph.D. recipients in science/engineering (S/E) fields awarded by US institutions in 2020, 46% (approx. 15,000) held temporary visas, a lower bound estimation of “foreign students”. Among these 15,000 recipients with temporary visas, the largest portion came from China, at 37%, three times the proportion from India, the second largest sending country'
#OTD 28 June 1873 Alexis Carrel was born. A surgeon & biologist, he won the Nobel Prize in Physiology or Medicine in 1912 for pioneering vascular suturing techniques. He invented the first perfusion pump with Charles A. Lindbergh opening the way to organ transplantation. He was a leader in Vichy France's eugenics program.
Associate Research Scientist
Zuckerman Institute, Columbia University
See the full job description on jobRxiv: https://jobrxiv.org/job/associate-research-scientist-17/?feed_id=48635
#ScienceJobs #hiring #research
New York City #UnitedStatesUS #Researcher #Scientist
https://jobrxiv.org/job/associate-research-scientist-17/?feed_id=48635
‘It’s like Groundhog Day’: The cancer drug shortage isn’t new — and neither are the solutions https://www.statnews.com/2023/06/28/cancer-drug-shortage-generics-economics-solutions/
"The Outer Hebrides Palimpsest. (Edinburgh, Scotland, 1677).
Following the establishment of the Man in the Iron Mask’s identity by use of the correspondence and shopping lists of his jailor, Saint Mars, the Margrave embarked on a reanalysis of one his cartographic collection’s most celebrated collection items, the Outer Hebrides Palimpsest. The connection was tenuous at best: a group of Waldensians fleeing the brutal suppression of the sect in Piedmont arrived at the remote islands at around the time the map was produced. In keeping with our founder’s original mission, the process arrived at no useful conclusions – one unfortunate effect is the damage you see here, the Margrave's effort at redacting the map."
Prof. Horst Manfrenjensenden, Ph.D.
Head of Collections, von Willebrand Trust. Dresden, December 12th, 2022.
#Art #Print #Printmaking #Etching #Handmade #Cartography #ArtGallery #Oubliette
@anaanajottajotta @consta_arouca@madparreira @jorgenesbitt
Oubliette" Exhibition at Biblioteca Camoes, Lisbon (Largo do Calhariz, 17). Show runs until the end of June.
#Introduction
Hello #ScienceMastodon. We are the European Summer School on Stem Cell Biology & Regenerative Medicine
Our summer school, founded in 2005, is a not-for-profit event run by academic stem cell biologists
We provide intensive training led by a stellar array of field-leading scientists, with an emphasis on interactive discussions on the latest developments in the field
We also cover ethics, science communication and entrepreneurship.
Testimonials: https://www.stemcellsummerschool.org/testimonials
"We review how both TFH and TFR cells express helper and repressor factors that coordinately regulate the Ab response and how the line between these two subsets is less clear than initially thought."
#Immunology #GerminalCenter
'These data suggest that animals overexpressing folr-1 are deficient in their ability to adapt to changes in microbial metabolism, thus revealing an intriguing and non-canonical role of folate receptor in lifespan regulation.'
#Preprint #Celegans #metabolism
https://www.biorxiv.org/content/10.1101/2023.06.26.546484v1?med=mas
'This is a vision of hell. It is also a glimpse of the future. The Institute for Economics and Peace has estimated that by the middle of the century more than a billion people will be at risk of displacement because of ecological threats.'
The key words here are "locally acquired".
'In the last two months, at least five people, four in Florida and one in Texas, have been infected with malaria in the United States, the Centers for Disease Control and Prevention said in a health advisory on Monday. These are the first known cases of locally acquired malaria in the country since 2003.'
#Malaria #InfectiousDisease #publichealth
“Fascist” is not a term I use lightly, but the Silicon Valley vogue for administering performance-enhancing drugs to improve human capital is, well, fascist. My latest: https://newrepublic.com/article/173957/microdosing-silicon-valley-boss-dope-workers
Data management is always something you should plan out at the start of the project... but no one ever does
#DataManagement #DataScience
#cartoon #cartoons #comic #comics #instacomic #instacartoon
#academia #science #research
#errantscience
Gavi has approved adding a 6-in-1 vaccine to the roster of jabs it helps countries buy. There's hope this one will help in the effort to end #polio transmission & keep it gone after eradication. I wrote about this plan this last week. https://www.statnews.com/2023/06/23/polio-eradication-six-in-one-vaccine/
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com