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A functional link between lariat debranching enzyme and the intron-binding complex is defective in non-photosensitive trichothiodystrophy cell.com/molecular-cell/fullte

Artemisia Gentileschi was born #OTD in 1593.

Gentileschi is considered among the most accomplished seventeenth-century artists, initially working in the style of Caravaggio. She was producing professional work by the age of 15. via @wikipedia

#art #painting

Interesting article discussing narrative CVs - especially considering the upcoming changes to the ERC's evaluation procedures. Check back here this coming week to see more details! science.org/content/article/ho

🐦🔗: n.respublicae.eu/ERC_Research/

'Here, we analyzed subcellular distribution in micropatterned patient-derived melanoma cells and found that lysosome spreading scales with their aggressiveness.'

biorxiv.org/content/10.1101/20

'Tissue resident memory (TRM) T cells were detected for the first time within the valve, exhibiting a highly cytotoxic, activated, and terminally differentiated phenotype.'

biorxiv.org/content/10.1101/20

'So, in 1976, two colleagues and I organised the first meeting on DNA insertions. During this meeting, it became clear that geneticists working on bacteria, yeast, fruit flies, plants and animals were all studying the same phenomenon McClintock had discovered in her maize plants 30 years earlier.'

aeon.co/essays/why-did-darwins

'Mas mais impressionante era o respeito e consideração com que ele tratava todas as nossas perguntas, mesmo as mais ingénuas, incluindo quando confessava nunca ter pensado no assunto e nos prometia uma resposta para a semana seguinte. E, na semana seguinte, a resposta vinha, refletida, contemplada, dando a cada um de nós dignidade na relação intelectual e o sentido de que cada pessoa pode ter algo de valor a acrescentar. As palavras de Mattoso transmitiam conhecimento. A sua atitude, sabedoria.'
@ruitavares

publico.pt/2023/07/08/culturai

Malaria on a chip.

'A functional, multi-organ, serum-free system was developed for the culture of P. falciparum in an attempt to establish innovative platforms for therapeutic drug development. It contains 4 human organ constructs including hepatocytes, splenocytes, endothelial cells, as well as recirculating red blood cells which allow for infection with the parasite. '

nature.com/articles/s41598-023

'Os partidos de poder são indiferentes à ganância, aos jogos de poder e, no limite, à corrupção. Não é preciso ir mais longe do que o espectáculo degradante da recepção apoteótica a Pedro Nuno Santos.'
José Pacheco Pereira

publico.pt/2023/07/08/opiniao/

1/ Our team at HDT bio just posted a new paper to Molecular Therapy (sciencedirect.com/science/arti). Led by Senior Scientist Taishi Kimura, we investigated the distinct host responses to repRNA delivered by two different formulations: LION and LNP. LION, a cationic nanocarrier, binds RNA at the nanoparticle surface, whereas LNP encapsulates RNA. These different presentations create distinct surface properties and host responses.

'El cáncer abarca historias múltiples: científicas, personales, médicas, psicológicas. Es el mayor misterio que alguien puede resolver. Cada año surgen nuevas ideas y aproximaciones. Las tendencias vienen y van, pero el misterio sigue sin estar resuelto; y hay que conseguir resolverlo.'

elpais.com/ciencia/2023-07-08/

'Unexpectedly, this drug-repositioning study did not identify drugs that are currently used off-label to treat specific systemic disease manifestations of pSS (such as hydroxychloroquine, leflunomide, mycophenolate mofetil and prednisone) as potential candidates.'

nature.com/articles/s41584-023

Ukemochi is the Japanese Shinto goddess of food who was able to produce foods from her body. Unfortunately on one occasion when she was doing this, she offended the moon god Tsukuyomi. As a result he killed her which lead to the sun goddess Amateurasu banishing him to the far end of the sky.
More about ukemochi here:
curiousordinary.com/2023/04/uk
More about Tsukuyomi here:
curiousordinary.com/2021/08/ts
🎨Tatsuya Kosaka
#Folklore #mythology #JapaneseFolklore
@mythology @folklore

'Loss of TIM-1 enhanced the type 1 interferon response in B cells, which augmented B cell activation and increased antigen presentation and co-stimulation, resulting in increased expansion of tumour-
specific effector T cells.'

nature.com/articles/s41586-023

'The candidate from the conservative Popular Party had a chance to govern, but he needed the hard-right Vox party, which, in return for its support during council votes, received the deputy mayor position and a new administrative body to defend the traditional family. They inked their deal under the cross of the local church.'

nytimes.com/2023/07/08/world/e

“The truth of art keeps science from becoming inhuman, and the truth of science keeps art from becoming ridiculous.”
Raymond Chandler, in The Notebooks of Raymond Chandler.

'Mas mais impressionante era o respeito e consideração com que ele tratava todas as nossas perguntas, mesmo as mais ingénuas, incluindo quando confessava nunca ter pensado no assunto e nos prometia uma resposta para a semana seguinte. E, na semana seguinte, a resposta vinha, refletida, contemplada, dando a cada um de nós dignidade na relação intelectual e o sentido de que cada pessoa pode ter algo de valor a acrescentar. As palavras de Mattoso transmitiam conhecimento. A sua atitude, sabedoria.'
@ruitavares

publico.pt/2023/07/08/culturai

'De mapas de sombras a aplicaciones para encontrar fuentes donde beber agua y de sistemas de drenaje a techos blancos, las urbes buscan soluciones para lograr espacios frescos'

elpais.com/clima-y-medio-ambie

Malaria on a chip.

'A functional, multi-organ, serum-free system was developed for the culture of P. falciparum in an attempt to establish innovative platforms for therapeutic drug development. It contains 4 human organ constructs including hepatocytes, splenocytes, endothelial cells, as well as recirculating red blood cells which allow for infection with the parasite. '

nature.com/articles/s41598-023

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