Thiago Carvalho @cyrilpedia@social.cleverlibre.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
'One may even speculate that there might be individual microglial populations that are specialized to deal with the different pathological challenges of AD. Thus, microglial activation is an integral component of the amyloid cascade and not just an alternate disease-causing pathway unrelated to amyloid-driven events.'
#immunology #Neuroimmunology #alzheimers #Microglia
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3001694
Thiago Carvalho
boosted
Liberals in the German government: We're broke, we have to cut funding for anti #hatespeech #NGOs, sorry.
Also #liberals in the German government: We'll spend 1.6 billion € of yours on #AI with unknown benefits. Yay.
https://taz.de/Beratungsarbeit-von-HateAid-in-Gefahr/!5945064/
https://www.golem.de/news/aktionsplan-staatliche-milliardeninvestition-in-ki-geplant-2308-177032.html
#wasted #innovation #business #TechWontSaveUs #artificialintellgence #germany #FDP
Thiago Carvalho
boosted
Hi #ScienceMastodon! Today's Research Highlight from JCS is a great example of how publishing studies that re-test old hypotheses with modern, more sensitive methods can address #reproducibility. Sabrina Holland and Gianluca Gallo from Temple University in Pennsylvania reexamine whether actin dynamics in growing axons are as much of a drain on neuronal energy homeostasis as previously reported.
Revisiting actin dynamics and energy homeostasis in growing neurons
https://journals.biologists.com/jcs/article/136/16/e136_e1602/325934/Revisiting-actin-dynamics-and-energy-homeostasis
Thiago Carvalho
boosted
One more time...
UK political leaders absolving themselves of breaking the rules.
From the same guy who issued the drilling licences for his family.
Thiago Carvalho
boosted
Trade Card of Nathaniel Longbottom, “Supplier of Skeletons in St. Thomas's Street, Southwark,” late 18th century. Longbottom would likely have had interactions with bodysnatchers (or “resurrectionists”) to help him procure skeletons for his shop.
Image: Wellcome Collection
#histodons #histodon #history #histmed #histsci #sciart #skeleton #illustration
'Several indicators suggest that the quality of Chinese research is improving. Between 2012 and 2021, China’s share of the top 1% of the most-cited papers grew by 40%, while the US’s share dropped by 18%. The US is still ahead, according to Clarivate’s data, but the gap is narrowing, and other estimates suggest that China has already overtaken the US.'
'I have said in one of my few forays into nonfiction (On Writing) that you can’t learn to write unless you’re a reader, and unless you read a lot. AI programmers have apparently taken this advice to heart.'
https://www.theatlantic.com/books/archive/2023/08/stephen-king-books-ai-writing/675088/
' En todos los escenarios, hay ocho regiones españolas que están entre las más perjudicadas en la reducción del número de pernoctaciones. Son Baleares, Murcia, la Comunidad Valenciana, Extremadura, Andalucía, Comunidad de Madrid, Castilla-La Mancha y Cataluña. Además, España en su conjunto es tras Chipre, Grecia y Portugal el país europeo que más visitantes perderá.'
Thiago Carvalho
boosted
My favorite paper that I've read this year — a look at how confusion between inferential uncertainty and outcome variability creates all sorts of problems — is now out in PNAS.
Here's the paper: https://www.pnas.org/doi/abs/10.1073/pnas.2302491120
Here's the thread I wrote about the preprint last April: https://fediscience.org/@ct_bergstrom/110267907188002904
Thiago Carvalho
boosted
'Maisaka: Ferryboats on the Sea at Imagiri' from the series 'Famous Sights of the Fifty-three Stations' also known as the 'Vertical Tokaido' - Utagawa Hiroshige, 1855.
#JapaneseArt #ukiyoe #Hiroshige #Japan
“This health system had figured out how to support people with chronic diseases – find them, keep them, ensure they stuck to their treatment,” she says. “We had already built a chronic-care system, so why not expand that to other conditions?”
#publichealth
Thiago Carvalho
boosted
2023 is on track to be the hottest year on record, but we still have Republicans claiming the climate crisis is a "hoax." What planet are they living on?
Thiago Carvalho
boosted
Both incredible and sad.
Discovered in the deep: an octopus’s garden in the shade
'Although all complement pathways have been implicated in COVID-19 pathogenesis, the upstream drivers and downstream effects on tissue injury remain poorly defined. We demonstrate that complement activation is primarily mediated by the alternative pathway, and we provide a comprehensive atlas of the complement alterations around the time of respiratory deterioration.'
Thiago Carvalho
boosted
#IDMastodon #Immunology @nih_nhlbi #CovidIsNotOver #WearAMask😷 #getvaccinated #SARSCoV2, 🦠 that causes #COVID19 can cause lasting damage to energy production by #mitochondria in many organs of the body.Stopping the virus from hijacking mitochondrial energy production may be a novel way to prevent serious complications from #SarsCoV2 infection.
https://www.nih.gov/news-events/nih-research-matters/sars-cov-2-can-cause-lasting-damage-cells-energy-production
'I suddenly remembered a patient on the Neurology Wards 15 years before, who had woken from sleep, one Christmas Day, to find ‘a strange leg’ in his bed. There was a Christmas party going on, and the only ‘explanation’ he could imagine was that one of the nurses, as a joke, had filched a leg from the Anatomy Room, and slipped it under the covers as he slept.'
- Oliver Sacks @lrb
https://www.lrb.co.uk/the-paper/v04/n11/oliver-sacks/the-leg
Thiago Carvalho
boosted
🆕#blogpost: Daniela Mera-Rodríguez & colleagues explore the evolution of eusocial insects: They investigate the historical biogeography & transitions from colony life to social parasitism in the ant genus Myrmecia.
Pic: CC-BY-NC-ND doi.org/10.1016/j.ympev.2023.107825
https://blog.myrmecologicalnews.org/2023/08/24/biogeography-and-evolution-of-social-parasitism-in-bulldog-ants/
Thiago Carvalho
boosted
'These data support the potential use of IGF1 in combination with common γ-chain cytokines to drive homeostatic T cell expansion, both in vitro and in vivo, for cellular therapeutics and ex vivo gene editing.'
#immunology
Thiago Carvalho
boosted
On the Decoupling of Evolutionary Changes in mRNA and Protein Levels https://doi.org/10.1093/molbev/msad169 #science #evolution #biology #genome #evolgen_paper
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
