Thiago Carvalho @cyrilpedia@social.cleverlibre.org

The Hobbit was published on this day in 1937. Savor Tolkien's forgotten original drawings for the first edition https://t.co/vdFudXMKbI

'From next month Medicare, the taxpayer-funded healthcare system that covers 65mn US retirees, will for the first time get the power to negotiate lower prices directly with pharmaceutical companies for 10 of the most expensive drugs.'

https://www.ft.com/content/7e45d513-017f-4e68-9b23-68b974a21f1c

"Nevertheless, news continues to be made every day based on the statements and activities of newsworthy people—politicians, bankers, business leaders, artists, entertainers, and athletes. Other people are ignored unless they’ve been involved in a crime or a scandal, or suffered an accidental or violent death. If they have lived lawfully and uneventfully, and died of natural causes, obituary editors do not assign reporters to write about them. They are not newsworthy. They are essentially nobodies. I wanted to specialize in writing about nobodies."

- Gay Talese

https://www.theatlantic.com/ideas/archive/2023/09/gay-talese-memoir-excerpt/675359/

'The charged status of race in the census did not end there. Contemporary arguments about racial ‘degeneration’ and the changing composition of the US population fed directly into the census of 1920, in which almost half the form was devoted to questions about where people were born and what their parents’ mother tongue was.'

https://www.lrb.co.uk/the-paper/v45/n18/john-lanchester/get-a-rabbit

This story is crazy. A small town Texas bigot tries to run a gay couple out of town, but in the process of fighting back, they discover that the bigot has been embezzling hundreds of thousands of dollars from the town. So she apparently burned down the town hall, fled the state, and is living homeless in a Colorado park.

#Texas

https://themessenger.com/news/2-gay-dads-helped-uncover-767000-embezzlement-scheme-in-texas-town-where-officials-called-them-homophobic-slurs

They carry a gene for ALS but aren’t sick. What does medical research owe them?

https://www.statnews.com/2023/09/21/als-gene-carrier-riluzole-toferson/?utm_medium=social&utm_source=mastodon&utm_campaign=mastodon_organic

Our September issue includes a new Letter (https://doi.org/10.1093/gbe/evad105) from Deborah Charlesworth et al. that provides a counterpoint to a GBE article published in March by Lydia Fong et al. (https://doi.org/10.1093/gbe/evad030), along with a response from Fong et al. (https://doi.org/10.1093/gbe/evad128). #science #evolution #biology #genome #evolgen_paper

Nature’s take on the IIT as consciousness debate:

https://www.nature.com/articles/d41586-023-02971-1

Online Now: Hormone-induced enhancer assembly requires an optimal level of hormone receptor multivalent interactions https://www.cell.com/molecular-cell/fulltext/S1097-2765(23)00690-1?rss=yes&utm_source=dlvr.it&utm_medium=mastodon

Just a note that AlphaMissense is not the "Alphafold for point mutants" that some seem to be saying it is.

"Notably, AlphaMissense does not predict the structural changes of the mutated amino acid sequences but instead predicts pathogenicity as scalar values."
#StructuralBiology @strucbio

Accurate proteome-wide missense variant effect prediction with AlphaMissense | Science https://www.science.org/doi/10.1126/science.adg7492

@proteomicsnews blog post | It's September 21st! There is a mass spec symposium all day in Rockville today! | https://proteomicsnews.blogspot.com/2023/09/its-september-21st-there-is-mass-spec.html #proteomics

'Son los retrovirus endógenos humanos (HERV, por sus siglas en inglés), reliquias virales sin capacidad infectiva que se quedaron en el organismo tras infecciones que sufrieron nuestros ancestros hace millones de años.'

https://elpais.com/salud-y-bienestar/2023-09-20/el-misterioso-rol-de-los-virus-ancestrales-incrustados-en-el-adn-humano.html

'Some selection-based theories propose that genome streamlining, favoring smaller genome sizes, is advantageous in nutritionally limited environments, particularly under P-limitation. To test this prediction, we conducted several experimental evolution trials on clonal populations of a facultatively asexual rotifer that exhibits intraspecific variation in genome size.'

https://academic.oup.com/evolut/advance-article/doi/10.1093/evolut/qpad144/7277129?searchresult=1

"The moment you and your story are overwhelmed by the furious storm of the times - that's when the real novel begins."
Walter Mosley, Elements of Fiction.

#books #bookshelf #writing #bookstodon