Thiago Carvalho @cyrilpedia@social.cleverlibre.org

Soaring congenital syphilis rates in US risk lives of thousands of babies https://www.theguardian.com/society/2023/oct/17/congenital-syphilis-crisis-us-biden-administration?

Postdoctoral Fellow: Molecular Genomics

Imperial College London

Interested in how cells control their DNA replication? So are we! Join us for a postdoc to explore how key regulators affect genome stability.

See the full job description on jobRxiv: https://jobrxiv.org/job/imperial-college-london-27778-postdoctoral-fellow-molecular-genomics/?feed_id=62574

#ScienceJobs #hiring #resear...
https://jobrxiv.org/job/imperial-college-london-27778-postdoctoral-fellow-molecular-genomics/?feed_id=62574

Until I worked on this piece, I had no idea how out of control blood pressure still is for most people. Estimates are that only one fifth of those with high blood pressure manage it effectively. New RNA drugs that may only require dosing two to four times a year could really help, but at what cost? My latest Clinical Pipeline column.

#DrugDevelopment #DrugDiscovery #RNAdrugs #Pharma

https://www.nature.com/articles/d41591-023-00091-x

"Altogether, these data demonstrate that MMRd in these models is not sufficient to increase immunogenicity or sensitivity of tumors to ICB, alone or in combination with chemotherapy, in stark contrast to previous reports in cell-line transplant models"

https://www.nature.com/articles/s41588-023-01499-4

Happy birthday to trailblazing #programmer & #computer scientist, Beatrice "Trixie" Worsley. My #linocut shows Worsley seated at the first computer in Canada, the FERUT (which she named) & a flow diagram of one of her programs.⁠
⁠
Trixie Worsley earned one of the first doctorate in computer science anywhere, & was supervised by Douglas Hartree and Alan Turing at Cambridge. 🧵1/n

#WomenInSTEM #printmaking #sciart #histstm #physics #computerscience #programming #linocut #MastoArt

Questions about the origin of COVID-19 have cast a chill over American virus research, drying up funding and intensifying debates over how it's done. https://www.japantimes.co.jp/news/2023/10/18/world/science-health/lab-leak-virology-research/?utm_content=buffer0e679&utm_medium=social&utm_source=mastodon&utm_campaign=bffmstdn #worldnews #sciencehealth #medicine #vaccinations #pharmaceuticals #health #covid19

Retraining the brain for better vision

Professor Mark Bear's research on brain plasticity spins off a promising candidate to treat amblyopia, or lazy eye.

https://news.mit.edu/2023/mark-bear-retraining-brain-for-better-vision-1012

#neuroscience #MIT

More Than a Powerhouse: How Mitochondria Help to Build an Embryo

In this new post, Alexandra MacColl Garfinkel tells the story behind the paper "Mitochondrial leak metabolism induces the Spemann-Mangold Organizer via Hif-1α in Xenopus"🐸:

https://thenode.biologists.com/more-than-a-powerhouse-how-mitochondria-help-to-build-an-embryo/

If you post a #preprint, you can:
📅 set the release date for your research
🧪 others can build off your idea quicker
💬 you can receive valuable feedback
👀 and gain attention for your #research

Would you like to be featured in the Preprint Story Card?
ASAPbio ambassadors are developing new efforts to promote preprint adoption across India.
We invite India-based researchers to fill out the survey to be featured in the #PreprintStories Card.

https://docs.google.com/forms/d/e/1FAIpQLScKR_9LZcUYaLuZWhuc_Cv5i8OmaQMeEM66_h9HN4XK2_L1ew/viewform

#introduction update 👨‍🔬

I study #immune #evolution, including host-#pathogen interactions. My work has focused on #antimicrobial #defense #peptides which are like #antibiotics coded by the #genome . A key focus is #immunity-#microbiome interactions 🦠

See Hanson et al. (2023 Science) 🍃🍄🍌: https://ore.exeter.ac.uk/repository/bitstream/handle/10871/133708/Hanson_etal_2023_DptB_v4.pdf?sequence=3

I also talk #ScientificPublishing, #preprint, #openscience, and #academicchatter.

See:
https://fediscience.org/@MarkHanson/111147239095599059

@wellcometrust ECA and @SNF_ch research fellow in UoE UK. Cheers! 👋

Every year, Nikon hosts an image competition where all the photos are taken with a #microscope (doesn't have to be their brand scope). This year's winners were announced today and I wrote about it here: https://www.forbes.com/sites/evaamsen/2023/10/17/image-of-optic-disc-wins-annual-microscopy-competition/?sh=54be0e3a27de #WroteThis #science #biology

Paleontologists recently found bonebeds in the Navajo Sandstone near #LakePowell that hold rare #fossils of synapsid reptiles, which are #reptiles with mammal-like features. The discovery could shed light on the connection between mammals and reptiles.
#Utah #Arizona #drought
https://www.azcentral.com/story/travel/arizona/2023/10/17/lake-powell-fossils-found/71155684007/

Herman Melville's Moby-Dick is first published as The Whale # in 1851.

Melville first proposed the British publication in a June 27, 1850. At the end of May 1851, he delivered the bulk of his manuscript. In the October 1851 issue of Harper's New Monthly Magazine "The Town Ho's Story" was published, with a footnote reading: "From 'The Whale'. The title of a new work by Mr. Melville, in the press of Harper and Brothers, & now publishing in London by Mr. Bentley."

https://gutenberg.org/ebooks/15

#books

🧬 Bioinformatics is a maze of file formats, but you don't always need a special parser to get them into R! 📊 Many files are simply text-based tables with a dump of ‘#’ commented metadata up top. 📜 Use 'comment.char' in 'read.table' or 'comment' in 'read_table', its worth a shot #Bioinformatics #RStats

Just a small printed "s" waiting to become an illuminated initial in this 1503 print. The small "s" indicates: please include a colored big "S" after the print run. Early printed books kept this illuminating tradition from the manuscript age.

The page with the left space for the to be illuminated initial is part of the "Epistolarum D. Francisci philelphi equitis aurati..." Have a look: https://sammlungen.ulb.uni-muenster.de/hd/content/titleinfo/6526468

#BookHistory #histodons