Androgen deprivation + anti-PD1 trial for #prostatecancer.
"These data provide a reasonable therapeutic rationale to combine ADT with immunotherapy, thus leveraging anti-tumor immunity while mitigating the ADT-mediated induction of suppressive mechanisms. To that end, we designed and initiated the PRIME-CUT Phase II trial (NCT03951831) treating men with metastatic castration-sensitive prostate cancer (mCSPC) with a combination of standard of care chemo-hormonal therapy and anti-PD-1 immunotherapy using the anti-PD-1 immunotherapy cemiplimab."
#immunology #immunotherapy
https://www.cell.com/cancer-cell/fulltext/S1535-6108(23)00362-8
While I wait for my copy of my friend Dann McDorman's debut novel "West Heart Kill" to arrive, I enjoyed this podcast interview.
"When Claudia Goldin received her Nobel Memorial Prize in Economics, she was only the third woman to receive the award after Esther Duflo (2019) and Elinor Ostrom (2009). It was the first time in the history of the 54-year-old prize that women held more Nobels in economics than the uncles of Larry Summers (Paul Samuelson and Kenneth Arrow). An anecdote, but it illustrates the level of representation of women in economics."
"Large outbreaks of diseases that primarily kill children are spreading around the world, a grim legacy of disruptions to health systems during the Covid-19 pandemic that have left more than 60 million children without a single dose of standard childhood vaccines."
https://www.nytimes.com/2023/11/25/health/vaccines-children-zero-dose.html
I second Mark Kermode: Ken Loach's Land & Freedom (1995) is a superb film.
Watch it if you have the chance.
Just when I'd finally found good kimchi in Lisbon!!
"The antibiotic resistome was further illustrated in traditionally fermented food samples, and antibiotic-resistant bacteria were isolated from approximately 90% of the retail kimchi and all artisan cheeses assessed in this pilot screening."
#Preprint #Microbiology #antibioticresistance
His historical works include biographies of Oliver Goldsmith, Muhammad, and George Washington, as well as several histories of 15th-century Spain that deal with subjects such as the Alhambra, Christopher Columbus, and the Moors. Irving served as American ambassador to Spain in the 1840s.
*Insert your "this is deeply unfair to drug dealers" comment here*
'Mohamed Adow, the director of the thinktank Power Shift Africa, said: “The Saudi government is like a drug dealer trying to get Africa hooked on its harmful product."
https://www.theguardian.com/environment/2023/nov/27/revealed-saudi-arabia-plan-poor-countries-oil
Cancer concerns us all one way or the other.
With
https://nitter.cz/search?q=%23EUCancerPlan
, we're taking important steps & changing the prognosis for every cancer patient & survivor, working on better prevention and earlier detection.
28
https://nitter.cz/search?q=%23EU4Health
-financed projects:
https://europa.eu/!7yFV8y
https://nitter.cz/search?q=%23HealthUnion
🐦🔗: https://nitter.cz/EU_Health/status/1729403417796202511#m
[2023-11-28 07:34 UTC]
'(...) even if European far-right parties do not overturn democracy, they can pull political debate on to their turf. The most obvious trait they share is a powerful hostility towards immigration — particularly of Muslims — and a willingness to contemplate measures that have previously been dismissed as impractical, intolerable or illegal.'
https://www.ft.com/content/8384228d-8156-4134-8eb4-035c068704b9
"The first thing you should know about Social Security is that the actual numbers don’t justify the apocalyptic rhetoric one often hears, not just from the right but from self-proclaimed centrists who want to sound serious."
https://www.nytimes.com/2023/11/27/opinion/nikki-haley-social-security.html
'Filho’s native city of Recife has also been subject to similar remodellings, as shown in the second and third parts here, through the decline of its cinema houses. As they fall into dereliction, it feels like a form of collective dementia, robbing its citizens of a shared cultural continuity.'
Paris mayor quitting Elon Musk's 'global sewer' platform X before 2024 Olympics https://www.cbc.ca/sports/olympics/summer/anne-hidalgo-paris-mayor-quitting-x-olympics-1.7040900?cmp=rss
I second Mark Kermode: Ken Loach's Land & Freedom (1995) is a superb film.
Watch it if you have the chance.
Would you like a tool to help people understand #OpenScience quickly and easily?
Come hear my talk Wed, Nov 29, 2pm CET:
"What is Open Science for?"
Details: https://osi-luebeck.de/what-is-open-science-for/
Email open.science@uni-luebeck.de for a link.
'Anne Hidalgo, the mayor of Paris, announced Monday on X, formerly Twitter, that she was quitting the social media site because it had devolved into a “gigantic global sewer” for disinformation, hatred, anti-Semitism and racism, and a “tool for destroying our democracies.”
https://www.nytimes.com/2023/11/27/business/anne-hidalgo-x-twitter.html?smid=tw-share
Meet your colleagues and discuss a new preprint over lunch during Cell Bio 2023 🥳
We’re pleased to announce preprint launch parties organized by ASAPbio during Cell Bio 2023 (Boston, MA, USA)! These lunch events are not formally affiliated with ASCB/EMBO, but will be held Monday and Tuesday, Dec 4 and 5, at a conference room at street level about a 10’ walk from the conference center.
To learn more and RSVP: https://docs.google.com/forms/d/e/1FAIpQLSc2qZ3jBUPDsCNy5yHjux44u0J67okwhYAwQBgHtSVQgv1jjQ/viewform?usp=sf_link
Important new A.I. report for breast cancer leading to the potential of sparing chemotherapy for many. The 1st comprehensive analysis of both cancerous and non-cancerous tissue in hundreds of thousands of patient tissues ->HiPS score
🇫🇷 The French welfare agency uses an algorithm to detect potential fraudsters. Every month, it ranks the households of 32 million people, including 13 million children, with a "risk score".
For the first time, @LaQuadrature obtained its source code and could run it.
The criteria that increase the risk score are
- being poor,
- living in a poor neighborhood,
- being a single mother,
- being unemployed,
- having a disability.
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com