Thiago Carvalho @cyrilpedia@social.cleverlibre.org

Nuclear RNA catabolism controls endogenous retroviruses, gene expression asymmetry, and dedifferentiation https://www.cell.com/molecular-cell/fulltext/S1097-2765(23)00903-6?rss=yes&utm_source=dlvr.it&utm_medium=mastodon

NPR: The Biden administration said it has approved the emergency sale of nearly 14,000 rounds of ammunition worth more than $106 million as Israel intensifies its military operations in southern Gaza.#news #NPR https://www.npr.org/2023/12/09/1218407156/israel-tank-ammunition-sale-gaza-congress-state-department

The good news: We have a breakthrough cure for sickle-cell disease, using CRISPR and gene-editing technology.

The bad news: It’s owned by a private company that will charge $2.2M for a course of treatment.

Pharmaceutical research should be publicly-funded, and its results should go directly into public domain, where private providers can compete on price for manufacture and distribution. For a fraction of the money we spend on missiles and remote military bases, we can save so many lives instead.

“FDA approves cure for sickle cell disease, the first treatment to use gene-editing tool CRISPR”

#healthcare #medicine #capitalism

https://www.nbcnews.com/health/health-news/fda-approves-cure-sickle-cell-disease-first-treatment-use-gene-editing-rcna127979

Change is coming in scientific publishing! We are collecting feedback through focus groups on our proposal 'Towards Responsible Publishing'. Let's shape the future of scholarly communication together!

#ResponsiblePublishing #ScholComm #Plan_S

https://www.coalition-s.org/towards-responsible-publishing/

With the support of @researchconsulting and
@cwts

'The results showed that an organ’s biological age is linked to disease risk. For example, roughly 2% of participants had accelerated heart ageing — that is, their levels of blood proteins relating to heart ageing differed substantially from those of other people of the same age. Having a prematurely old heart was linked to a 250% increased risk of heart failure, the authors found.'

https://www.nature.com/articles/d41586-023-03821-w

“Ela estava determinada em lutar por justiça e sabia que haveria um “preço” a pagar pela audácia de uma mulher negra, da periferia, levar à justiça um agente da polícia, num concelho em que 76% das queixas contra agentes policiais foram arquivadas entre 2014 e 2019."

https://www.publico.pt/2023/12/07/opiniao/opiniao/silencio-nao-protegera-2072812

"The assumption was that once the benefits of open access were explained to them, researchers would voluntarily embrace it – primarily by self-archiving their research in institutional or preprint repositories. But while many researchers were willing to sign petitions in support of open access, few (outside disciplines like physics) proved willing to practice it voluntarily."

https://scholarlykitchen.sspnet.org/2023/12/07/where-did-the-open-access-movement-go-wrong-an-interview-with-richard-poynder/

"Heuer et al. then set out to find which computational model of evolution was able to recreate the anatomies of the cerebellums found in the different mammalian species. They found that a stabilising model – that is, when animals that are straying away from their common ancestor randomly evolve back to these initial properties – worked best. Using this model, Heuer et al. estimated that the organism most mammals descended from probably had a cerebellum similar to the one found in an animal known as the rock hyrax (Figure 1B)."

https://elifesciences.org/articles/93122?utm_source=linkedin&utm_medium=social&utm_campaign=organic_insights

Stop Treating AI Models Like People!

No, they haven’t decided to teach themselves anything, they don’t love you back, and they still aren’t even a little bit sentient.

Sasha Luccioni and I have had enough of this nonsense & discuss in a joint essay:

https://garymarcus.substack.com/p/stop-treating-ai-models-like-people

Israel presses ahead with bombarding Gaza, including areas it told Palestinians to evacuate to https://apnews.com/article/7625885f326b5a294479c6e8fc61355c

nowhere in this @NPR article does it mention that large corps raked in epic profits while still raising prices on necessities like food and gas; it wasn't just 'inflation'. https://www.npr.org/2023/12/09/1218291541/biden-economy-inflation-jobs

"Shortages have occurred regularly since at least the early 2000s, when national tracking began. Hundreds of drugs, in every major therapeutic category, have been unavailable for some period. The average drug shortage lasts about 1.5 years"

https://www.nytimes.com/2023/12/06/opinion/drug-shortages-pharmaceuticals.html

'Pintor, escultor, escritor y activista, Pérez Esquivel la conoció de cerca. En 1977, mientras promovía enlaces entre organizaciones sociales para defender a las víctimas de los regímenes militares en toda Latinoamérica y lideraba la resistencia no violenta contra las dictaduras, fue tomado preso por la de Jorge Rafael Videla. Fue encarcelado y torturado durante 14 meses, y los militares argentinos se lo llevaron en uno de los vuelos de la muerte, desde donde lanzaban a los prisioneros sedados al Río de La Plata.'

https://elpais.com/argentina/2023-12-07/adolfo-perez-esquivel-el-dia-que-uno-deja-de-sonreirle-a-la-vida-es-que-uno-ha-sido-vencido.html

"Rebecca, 28, a full-time PhD student in biosciences from Liverpool, and her partner, an Australian national working in higher education, are among thousands of couples facing separation and financial uncertainty because of the government’s decision to overhaul immigration rules."

https://www.theguardian.com/world/2023/dec/07/everything-is-in-jeopardy-how-new-uk-visa-rules-are-tearing-families-apart

Bats & beyond

"Further analysis of IFITM repertoires in 205 mammals reveals that alternative splicing is a ubiquitous strategy for IFITM diversification, albeit less widely adopted than gene duplication."
#Preprint #immunology

https://www.biorxiv.org/content/10.1101/2023.12.04.569605v1

Postdoctoral position in fluid mechanics at Charles University

Charles University, Faculty of Mathematics and Physics

See the full job description on jobRxiv: https://jobrxiv.org/job/charles-university-faculty-of-mathematics-and-physics-27778-postdoctoral-position-in-fluid-mechanics-at-charles-university/?feed_id=67430

#fluid_mec...
https://jobrxiv.org/job/charles-university-faculty-of-mathematics-and-physics-27778-postdoctoral-position-in-fluid-mechanics-at-charles-university/?feed_id=67430

News in Proteomics Research blog post | Organ aging proteomic map shows the days of LCMS for proteomics are coming to an end! https://proteomicsnews.blogspot.com/2023/12/organ-aging-proteomic-map-shows-days-of.html

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#proteomics #prot-other

To complete the mammoth task of reversing the calamity of Brexit we need to keep growing in every corner of the UK. Will you join the European Movement today? https://www.europeanmovement.co.uk/membership
#brexit #ukpol #ukpolitics