"In addition, histological analysis of patients with ICI-associated myocarditis revealed a large number of T-cell infiltration in cardiac muscle, skeletal muscle, and tumor tissues, and further T cell receptor (TCR) sequencing of the infiltrating lymphocytes revealed a high degree of clonal amplification of all three, as well as muscle-specific antigens detected in tumor tissues, suggesting that the cardiac muscle and the tumor tissues express common antigens that are used as targets by ICIs to attack and cause myocardial injury, which may be one of the mechanisms of ICI-associated cardiotoxicity [63]."
#Immunology #Immunotherapy
https://www.sciencedirect.com/science/article/pii/S0753332223013860?dgcid=raven_sd_via_email#bib178
Portugal is an outlier with its miserable fixation on airtravel and highways.
"Amid concerns about climate change, demand for rail service is strong, and both governments and private investors are trying to keep up. Even Eurostar may see competition on its London-Paris route."
https://www.nytimes.com/2024/01/04/travel/europe-new-trains.html
'Spain and Italy are among the countries worst affected as hospitals struggle to cope with an influx of patients and coronavirus-era mask mandates are reintroduced in health facilities in some regions'
https://www.ft.com/content/449c4748-ef63-4f0a-b26e-4e528889fac4
Sloth candle holder. Glazed #stoneware by @hunchbacksociety
#art #artgallery #handmade #ceramics #pottery #artmastodon @madparreira.bsky.social
'The oral administration of peptides is not a new concept, and the challenges faced are best illustrated by considering the failure to date to produce a marketable oral formulation of insulin since its discovery in 1921'
https://link.springer.com/article/10.1007/s11154-022-09735-8
Still catching up. 😅 This Week in Virology for November 22, 2023: https://www.microbe.tv/twiv/twiv-1064/
The CDC released 70K+ more doses of the #RSV vaccines for babies. Get those shots! 💉
The anti-vaccine movement is starting to show in measles cases. Increase of 18% in cases and 43% increase in deaths worldwide from 2021 to 2022. Most of the #measles deaths are in young kids. 😔
#TWiVTLDR 1/
There is an unmarked mass grave full of dead black people the police murdered and covered up and most people will never know abt it or care
#DefundThePolice #ACAB
https://chicagocrusader.com/215-bodies-found-buried-behind-jackson-mississippi-jail/
'A number of employees debated Musk’s actions in the company-wide #social-watercooler channel, and, the day after, we woke up to find many of their accounts gone. “So is this like a Candyman situation?” someone posted. “Mention Elon three times and we get deactivated?”
https://www.newyorker.com/tech/annals-of-technology/what-we-lost-when-twitter-became-x
You’ve probably heard about The New York Times lawsuit against OpenAI. But the details are impressive: The NY Times provided 100 exhibits of ChatGPT completing articles almost word for word, and the suit seeks the deletion of all GPT models.
Could it succeed, and what would be the consequences? I spoke with general counsel Cecilia Ziniti and Techdirt editor @mmasnick about its chances.
Museu de Arte do Rio enaltece ancestralidade em mostra sobre joalheria afro-brasileira
SnapShot: DNA repair pathways https://www.cell.com/molecular-cell/fulltext/S1097-2765(23)00975-9?rss=yes&utm_source=dlvr.it&utm_medium=mastodon
Olá, pessoas!!
Tem post novo no blog Estante de Bibliotecária
Se você circulou pela internet nas últimas semanas talvez tenha visto uma manchete parecida com esta: “84% da população adulta do Brasil não comprou nenhum livro no último ano, aponta pesquisa”. Mas o que exatamente essa manchete alarmante significa?
É isso que comento nesse post
"Traditionalists may ask, “… is Microbiome Sciences just Microbiology, Ecology, or Genomics?” The answer is no. It does not simply fit into any one of those boxes, but rather it is the nexus of those and several other fields, thereby making it a unique synthesis—an intricate composite of field, wet lab, theoretical, and computational work aimed at decoding microbial interactions with hosts and with each other"
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002420
“When the Supreme Court overturned Roe…, it claimed to be removing the judiciary from the abortion debate. In reality, it simply gave the courts a macabre new task: deciding how far states can push a patient toward death before allowing her to undergo an emergency abortion.” From a good column on the law at issue in a case the Supreme Court today decided to hear, to decide whether state total abortion bans conflict with federal law requiring emergency care. https://slate.com/news-and-politics/2024/01/supreme-court-abortion-case-texas-dobbs.html #LawFedi
'Para mí escribir es eso, una forma de provocar un incendio sin cometer un delito. A los nueve años escribí mi primera poesía para no morir. La escritura es algo muy visceral, me estructura. Ahora he estado un tiempo sin escribir reportajes, solo editoriales, columnas, y pasó algo gracioso. Dejé de llorar.'
Online now: Automated identification of African carnivores: conservation applications https://www.cell.com/trends/ecology-evolution/fulltext/S0169-5347(23)00338-5?rss=yes&utm_source=dlvr.it&utm_medium=mastodon
'Yoshiwara: Floating Islands in Fuji Marsh' from the series 'Famous Sights of the Fifty-three Stations' also known as the 'Vertical Tokaido' - Utagawa Hiroshige, 1855.
#SwampSunday #ukiyoe #JapaneseArt #Japan #MtFuji
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com