Thiago Carvalho @cyrilpedia@social.cleverlibre.org

"Cell identity is generated from the epigenetic interpretation of the genome.”
On the second episode of the Helmholtz Pioneer Campus Podcast I discussed epigenetics & stem cells with Maria Elena Torres-Padilla, Boyan Bonev, and Wolf Reik.
#Epigenetics #StemCells #Ageing #Regeneration #SciComm #SciencePodcast

(All links go to the same episode on different platforms)

https://open.spotify.com/episode/6YOaHqznTuCRK0zBlUXqFN

https://www.pioneercampus.org/themenmenue-links/about-us0/index.html

https://podcasts.apple.com/de/podcast/helmholtz-pioneer-campus-podcast-series/id1718886869

https://player.admiralcloud.com/?v=4078154a-913d-4b2f-8ea6-c5d208d2b990

Scaling and merging macromolecular diffuse scattering with mdx2 | bioRxiv

Exciting if we can use this in refinement.
*Reads*

#StructuralBiology #Crystallography #MX

https://www.biorxiv.org/content/10.1101/2024.01.16.575887v1?rss=1

#IDMastodon #PedsID #CellularImmunology Infections in human newborns: severe and frequent, due to age-specific vulnerability. Can this be reconciled with the immense interindividual variability of clinical outcome observed for any neonatal infection?

https://www.sciencedirect.com/science/article/abs/pii/S0008874924000108?via%3Dihub

January 17, 1912, Captain Robert #Scott's expedition arrives at the South Pole one month after Roald Amundsen. All men will perish on their return journey, but the plant #fossils they collected will later prove continental drift 🌿

https://bbc.com/news/magazine-15384729?fbclid=IwAR1_KnaQD3QtPJ5FRpdCsI81HT9ST6htBeFGwDzs6G_NBqSYVnXGKqNg7d4

Lorne Proteomics | 31 Jan-3 Feb, 2024 | Mantra Lorne, Australia --- https://www.lorneproteomics.org/

---
#proteomics #prot-conf

"Thousands of people across Germany have taken to the streets for a fourth consecutive day to voice their opposition to the far-right populist AfD party after politicians from the party met neo-Nazis to discuss a “master plan” for the mass deportation of asylum seekers and German citizens of foreign origin." #Germany #fascism #racism #rightWingExtremism

https://www.theguardian.com/world/2024/jan/16/germans-take-to-streets-to-oppose-far-right-afds-mass-deportation-plan

"And for Christmas I got whooping cough. The diagnosis was a shock, not only due to the violence of the paroxysms that visited me in the night, but because I’d blithely assumed the thing had pretty much been vaccinated out of existence in the UK."

https://www.ft.com/content/a25bbf59-aa24-4313-a731-ef53976d1933

'The system that Romero’s team created is powered by a relatively simple machine-learning model that relates a protein’s sequence to its function, and proposes sequence changes to improve function. It delivers protein sequences for testing to lab equipment that makes the protein, measures its activity and then feeds the results back to the model to guide a new round of experiments. “We set and forget it,” Romero says.'

https://www.nature.com/articles/d41586-024-00093-w

Do any of you know about ancient Tamil music? Wikipedia says it's the predecessor of Carnatic music, which we find in southern India today, and it flourished from 500 BC to 200 AD.

It says the Tamils started with the pentatonic major scale. Then they developed a scale with seven notes. They then derived new scales by changing where you start the scales and also by "reallocating the pitch and beat of the notes" (huh?).

It says then they developed a 12-tone scale.

Eventually, the four original scales called maruthappann, kurinchippann, sevvaḻi and sadari (huh? what are those?) evolved into 103 different scales called panns.

It also says the most important modes of Tamil music are the Seven Great Modes - which happen to correspond precisely to the seven modes of the major scale in modern western music!

This is starting to sound almost too good to be true. And the talk page for the page on panns raises some questions about the source of this information. So I'm wondering about this stuff.....

https://en.wikipedia.org/wiki/Ancient_Tamil_music
https://en.wikipedia.org/wiki/Pann

Interested in a PhD position in knowledge graphs and graph technologies in the beautiful city of Vienna?

I'm offering a 4-year full-time (40h) position at TU Wien.

Application link (deadline February 1st, 2024):
http://jobs.tuwien.ac.at/Job/220960

#knowledgeGraphs
#graphDatabase

#solidarity

got infected with #COVID19 most likely in the hospital while getting #chemo. was in 6th week of tell. had a two week stoppage to recoup but, nope, now i have #LongCOVID and it's so bad they had to change my infusion because it triggered ANAPHYLAXIS.

people do not get the immunological angle of #COVID: if it doesn't kill you, it will maim you. (which, btw, was part of Nietzsche's point but since nobody really reads his books... anyways.)

@wendynather

'The skyrocketing cost of private rentals has left many people struggling to afford housing in Dublin and other Irish cities, pushing some to move abroad and others to commute long distances. The crunch has left teachers and social workers priced out of the communities they serve, professional couples unable to buy homes and people on lower incomes fearing homelessness.'

https://www.nytimes.com/2024/01/15/world/europe/ireland-housing-crisis.html

In the most recent episode of the Epigenetics Podcast, we talked with Kyle Eagen from Baylor College of Medicine about his work on BET Proteins and their role in chromosome folding and compartmentalization. #epigenetics #podcast #chromatin

Listen here: https://activemotif.com/podcasts-kyle-eagen

Antifungals are going the way of antibiotics—overused, hitting resistance

CDC urges clinicians to confirm fungal infections before prescribing antifungal medications.

https://arstechnica.com/science/2024/01/antifungals-are-going-the-way-of-antibiotics-overused-hitting-resistance/?utm_brand=arstechnica&utm_social-type=owned&utm_source=mastodon&utm_medium=social

"International postdoctoral scholars play an important role in the biomedical research ecosystem and should have compensation and benefits that are equal to that of their counterparts who are U.S. citizens/U.S. permanent residents and access to more federal grant opportunities to support their research careers."

https://acd.od.nih.gov/working-groups/postdocs.html

"Here, we identified a pattern of codon usage conserved across antibody genes. One feature thereof is the hyperutilization of codons that lack genome-encoded Watson-Crick transfer RNAs (tRNAs), instead relying on the posttranscriptional tRNA modification inosine (I34), which expands the decoding capacity of specific tRNAs through wobbling. Antibody-secreting cells had increased I34 levels and were more reliant on I34 for protein production than naïve B cells."
#Immunology

https://www.science.org/doi/10.1126/science.adi1763