Thiago Carvalho @cyrilpedia@social.cleverlibre.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
Pre ChatGPT, Kurt Vonnegut:
"Stories have very simple shapes, ones that computers can understand."
Thiago Carvalho
boosted
Libraries when you're homeless.
People talking about libraries, and I'd like to add from long-term experience that if you're homeless, those places are vital. Reading the newspaper while sitting on, y'know, a *chair*, hopefully a drinking fountain (No dehydration? Fancy) reading some books, not being too cold or too hot, lovely.
Oh, and you can sort out official stuff, which is handy when you ain't got an address. There was even a lady at one who liked to share food around. Like, you didn't eat it inside, obviously, but food? Nice.
Hell, just about the only things they didn't have were a place to wash or sleep, but you could learn stuff, rest a little, get out of the weather, not be on your guard all the time, (and can't get arrested, cause you're not 'loitering' in a library) and, here's the good part:
You could send your mind somewhere else. Like, without chemicals. You pick up a book and you just escape. That's priceless if you're homeless.
Which is the perfect price, cause you ain't got money.
A heart. A soul. A mind. That's what a library is. And bless em for existing.
Gonna stop there, cause I'm getting all teary and shit.
Thiago Carvalho
boosted
On March 24, 1912, American biochemist Sidney W. Fox was born. In search for the origins of life, Fox explored the synthesis of amino acids from inorganic molecules, the synthesis of proteinous amino acids and amino acid polymers called “proteinoids” from inorganic molecules and thermal energy, and created what he thought was the world‘s first protocell out of proteinoids and water.
http://scihi.org/sidney-fox-origins-life/
#biology #chemistry #biochemistry #proteinoids #historyofscience
"Here we show that heme strongly alters macrophage functional response to AC damage by exacerbating immune cell recruitment and impairing cell efferocytic capacity. In SCD, heme-driven excessive leukocyte influx and defective efferocytosis contribute to exacerbated tissue damage and sustained inflammation."
Thiago Carvalho
boosted
I never thought I would be a #mitochondria nerd, but here we are 🤷♂️🤣. Gonna enjoy reading doing of these articles.
---
RT @CellPressNews
'The new @Molecular_Cell special issue focuses on the #mitochondria. The review articles in this issue focus on the diverse cellular processes involving mitochondria and the approaches used to study them. Take a look. https://hubs.li/Q01J2qN20
https://twitter.com/CellPressNews/status/1639328223816450048
"The paper by White, Wu, and coauthors (10) starts out noting the confusion NSV causes in patient care when persistent viremia appears in someone on ART, then goes on to characterize the virus in four people in care with NSV. Remarkably, the viral populations in all four people contained mutations in the 5′-leader, also known as the 5′ UTR. These mutations inactivated the major splice donor (MSD) site, while still allowing the production of noninfectious virus particles from clonally expanded T cells."
Thiago Carvalho
boosted
Dear Berlin people: don’t forget to vote today. There’s a referendum for making Berlin climate neutral in 2030 (rather than 2045)! Thanks 💚💚💚
Alternative medicine:
"When it came to the treatment of diseases, the ancient Romans had no shortage of magical remedies, several of which involved iron nails. To cure epilepsy, the first-century historian Pliny the Elder advised driving a nail into the ground at the spot where the afflicted person’s head lay at the start of the seizure. The Romans hammered nails into doors to avert plagues and pounded coffin nails into thresholds to keep nightmares at bay. Nails from tombs and crucifixions were sometimes even worn around the neck as talismans against fevers, malaria and evil spells."
https://www.nytimes.com/2023/03/25/science/archaeology-ancient-rome-tomb.html
"In 1965, six years after the invention of the transistor, Moore forecast in a magazine article that the number of transistors and other components on a chip would double every year for the next decade. The prediction, dubbed Moore’s Law by an Intel colleague, has come to exemplify the onrush of technological advance ever since."
https://www.ft.com/content/fd02fefd-5312-432a-b1df-9668b438443d
“There is substantial risk, even if you’ve gotten all the vaccines,” Bernard Black, a law professor at Northwestern University who studies health policy, told me. More than 300 people still die from COVID each day, and the overwhelming majority of them are older. People ages 65 and up are currently hospitalized at nearly 11 times the rate of adults under 50.'
https://www.theatlantic.com/health/archive/2023/03/older-adults-covid-health-quality-of-life/673507/
Tools (#preprint)
"Our platform is built around a commercial instrument and integrates the handling and transfer of samples to and from the instrument, autonomous control of the instrument's software, and the algorithmic generation of sorting gates, resulting in walkaway functionality."
"Tumor-associated neutrophil (TAN) effects on glioblastoma biology remain under-characterized. We show here that 'hybrid' neutrophils with dendritic features - including morphological complexity, expression of antigen presentation genes, and the ability to process exogenous peptide and stimulate MHCII-dependent T cell activation - accumulate intratumorally and suppress tumor growth in vivo."
Thiago Carvalho
boosted
rock music history
'Having “something to say” does not necessarily make it worth saying; nor does it make the way you say it worth hearing.'
I really enjoyed this piece in tQ about Roger Waters of Pink Floyd. If you've encountered him recently in the news, this article tracks his crankiness and crackpot ideology as an echo of him wresting control of the Floyd between DSOTM and The Final Cut.
https://thequietus.com/articles/32741-pink-floyd-dark-side-of-the-moon-final-cut
"Understood as a form of erasure, decolonisation easily becomes an impossible or even undesirable task. But the problem with this interpretation is that it completely turns the meaning of decolonisation on its head. As I explained above, decolonisation entails first and foremost a profound and critical engagement with the colonial past, not its erasure."
https://aeon.co/essays/how-do-you-decolonise-the-english-language
'In Iraq and Kuwait they have become routine. Further west, even cities on the Red Sea such as Yanbu have seen 50°C. The Gulf is both at the centre of global hydrocarbon production and at the fore of its climatic effects. The average temperature rise in the region is already well over two degrees above pre-industrial levels.'
https://www.lrb.co.uk/blog/2023/march/fifty-degrees-in-the-persian-gulf
Thiago Carvalho
boosted
Following the delisting of MDPI's flagship journal IJERPH from Clarivate/Web of Science, I've penned a perspective. Hopefully helps folks understand where this came from & why it's such a big deal for #MDPI, and the implications moving forward. 
For perspective: IJERPH publishes more articles/y than PLOS One. 📊
See: bit.ly/ClarivateMDPI
Thiago Carvalho
boosted
The natural history of untreated pulmonary tuberculosis in adults: a systematic review and meta-analysis - The Lancet Respiratory Medicine
#TB #tuberculosis
https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(23)00097-8/fulltext#%20
Thiago Carvalho
boosted
For Throwback Thursday, from our Darwin Exhibition catalogue (2009), a shout-out to the trio at the Naval Museum in Lisbon that built our HMS Beagle model, Paula Galrinho, José Galrinho, and José Lopes. The riggings were very accurate, so that the 1.61m (1:27) long model used up three kilometres of thread!
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
