Thiago Carvalho @cyrilpedia@social.cleverlibre.org

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This is the way. 🙌🏻

How & why are #circadian rhythms maintained in red blood cells? Novel #haemoglobin #oxidation assay reveals it to be linked to body temperature regulation
A #RefereedPreprint c/o @ReviewCommons by John O‘Neill, Michael Hastings and coworkers
https://www.embopress.org/doi/full/10.15252/embj.2023114164

Tony Farrell discusses in his JEB100 Commentary the enormous species diversity and phenotypic plasticity of #fish #cardiac form and function and the potential of the fish #heart to mechanistically link organ form and function with their molecular underpinnings

#biology #zoology #comparativephysiology

https://journals.biologists.com/jeb/article/226/16/jeb245582/325873

'For example, loss of function of the microglial gene Trem2 renders microglia dysfunctional and causes an early-onset neurodegenerative syndrome, and Trem2 variants are among the strongest genetic risk factors for AD. Thus, restoring microglial function represents a rational therapeutic approach. Here, we show that systemic hematopoietic cell transplantation followed by enhancement of microglia replacement restores microglial function in a Trem2 mutant mouse model of AD.'

#Alzheimer #NeurodegenerativeDisease #Microglia #Neuroimmunology

https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(23)00251-5#%20

'In this Review, we synthesize recent progress made in understanding the interplay between the evolution of immunity induced by previous infections or vaccination and the evolution of seasonal influenza viruses driven by the heterogeneous accumulation of antibody-mediated immunity in humans.'

https://www.nature.com/articles/s41579-023-00945-8

@cyrilpedia @halama_immuno @victoralab thank you looping me into this thread.

Fascinating the ipsilateral vs contralateral #vaccination route though perhaps striking thing to me is the lack of a more pronounced signal. I. E. Yes there is a bit to gain from ipsilateral boosting but not a lot.

However I wonder if this could be a crucial variable in achieving effective / longer lasting #immunisation in those hard to vaccinate - e.g. Immunosuppressed

#immunology #vaccine #COVID19

'Both ipsilateral and contralateral vaccination induce a strong immune response, but secondary boosting is more pronounced when choosing vaccine administration-routes that allows for drainage by the same lymph nodes used for priming.'
#Immunology #covid19 #vaccines #SARSCoV2

https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(23)00308-0/fulltext

Predatory journals entrap unsuspecting scientists. Here's how universities can support researchers

https://www.nature.com/articles/d41586-023-02553-1

Cannot get any cooler than a write up in Rolling Stone magazine for this cool @PLOSBiology paper https://plos.io/47zOgve
Pink Floyd sons reconstructed from the brain waves of people thinking about it

#brain #neuroscience #rock #PinkFloyd
https://www.rollingstone.com/music/music-news/pink-floyd-song-reconstructed-brain-activity-1234807287/

I want to highlight the work that went into the revision of the manuscript, crediting the contribution of lab members and collaborators, as well as give an overview of the Review Commons process we used (see https://www.reviewcommons.org/) 2/23

I've not been here much lately, but here's a bit more about our paper just out in the Journal of Cell Biology, “Presynapses contain distinct actin nanostructures” (Twitter trained me to come up with short titles 🤏 and long threads 🧵, which are also doable in Mastodon I hope) 1/23
https://rupress.org/jcb/article-abstract/222/10/e202208110/276185/Presynapses-contain-distinct-actin 1/23

Bioinformatician / Computational Biologist / Systems Immunologist (f/div/m)

Leibniz Institute for Natural Product Research and Infection Biology (Leibniz-HKI)

We invite talented and highly gifted candidates to apply as
Bioinformatician / Computational Biologist / Systems Immunologist (f/div/m)

Se...
https://jobrxiv.org/job/leibniz-institute-for-natural-product-research-and-infection-biology-leibniz-hki-27778-bioinformatician-computational-biologist-systems-immunologist-f-div-m/?feed_id=55275

Proteogenomic data and resources for pan-cancer analysis | https://www.cell.com/cancer-cell/fulltext/S1535-6108(23)00219-2 #proteomics

“He could actually read a room and understand how to make it a meaningful experience,” says Hesse, recalling that 1966 Monterey jazz festival performance. “From the first note, he had the people in the palm of his hand and then took them on a journey throughout the entire set.”

https://www.theguardian.com/music/2023/aug/14/i-was-transformed-the-power-of-brazilian-jazz-legend-bola-sete