Thiago Carvalho @cyrilpedia@social.cleverlibre.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
Bad news for Bayer's factor XIa inhibitor.
"The German company on Monday said its Oceanic trial studying asundexian as a treatment for atrial fibrillation had shown “inferior efficacy” compared with standard treatment."
https://www.ft.com/content/86e6009a-a252-4a52-a4e4-930a50ef2d5a
Thiago Carvalho
boosted
Measles warning amid 'devastating resurgence' of life-threatening diseases as vaccination rates miss targets
#IDMastodon #medicine #InfectiousDiseases #vaccine #vaccination #measles
> The Royal College Of Paediatrics And Child Health said many doctors would not have previously seen symptoms associated with measles in their careers.
Thiago Carvalho
boosted
Provenance and Clinical Benefit of Medicines Introduced to the French Market, 2008 to 2018
"...three-fourths of the new #medicines entering the French market between 2008 and 2018 delivered no additional clinical benefit..."
"...medicines originating in the academic setting were graded to have better clinical benefit than those originating in the commercial setting..."
Thiago Carvalho
boosted
The world’s 1st gene therapy for #sicklecelldisease has been approved in the UIK. Casgevy (jointly created by #CRISPRTX & #Vertex #pharma is the first #medicine licensed using the gene editing tool #CRISPR, & offers hope to 1000's as an alternative to the treatment of arduous #bone marrow #transplants.
https://apnews.com/article/sickle-cell-gene-therapy-treatment-uk-first-9bcf7c7d8b8909fb06e137fee17c767c
Thiago Carvalho
boosted
#IDMastodon #Immunology #viralimmunology A summary of A viral #RNA molecule activates the bacterial immune system during infection& how bacterial cyclases sense infection sense.
https://www.nature.com/articles/d41586-023-03364-0?utm_medium=Social#ref-CR3
Viral infection triggers the production of cyclic GMP–AMP synthase (cGAS), an enzyme that synthesizes cyclic GMP–AMP (cGAMP) to activate the downstream effector response.
https://www.science.org/doi/epdf/10.1126/science.1232458
Thiago Carvalho
boosted
How many #species are there on Earth? Projections have ranged from the millions to the trillions.
This Perspective looks at how a 2011 #PLOSBiology study transformed this field and what still needs to be done to find a definitive answer.
Thiago Carvalho
boosted
So I tried #bluesky and it looks very much like #twitter, another for-profit platform with algorithms that have a danger of creating mobs, but in addition it is invite-only and has no functionality for literature bots. So far #mastodon looks better for #academicchatter
'As gay man, Rustin was forced to live with the constraints and prejudices of the time, including beatings and arrests. In 1953 he spent 50 days in jail and was registered as a sex offender after being discovered having sex in a parked car in Pasadena, California (he was posthumously pardoned). But he refused to hide his sexuality.'
https://www.theguardian.com/film/2023/nov/21/bayard-rustin-movie-lgbt-civil-rights-netflix
'Barnier was mellowed by age and hikes in the French Alps. In 2020, some British newspapers suggested he might have been Downing Street’s Covid “patient zero” who infected Prime Minister Boris Johnson. He swallowed his fury.'
https://www.ft.com/content/6ee16212-c748-44df-8698-b646f722deb7
Thiago Carvalho
boosted
nice portrait of science sleuth Elisabeth Bik
https://www.discovermagazine.com/the-sciences/science-sleuth-looks-to-expose-research-fraud
#fraud #researchintegrity #misconduct #science #publishers
Thiago Carvalho
boosted
Deficiency of miR-221/222 lowers lymphoid multipotency & raises stress-induced #granulopoiesis, without affecting #BoneMarrow homing of #HematopoieticStemCells, suggesting that boosting miR-221/222 might improve efficacy of #transplantation #PLOSBiology https://plos.io/47mYBds
"Thematically, this is of a piece with his recent interview with Deadline, in which he started to warn about the dangers of AI, only to end up boasting about his readiness for the apocalypse (“We are all completely fucked. We’re back to candles and matches. Do you have candles and matches at home? I live in France, so I do.”)."
https://www.theguardian.com/film/2023/nov/20/ridley-scott-napoleon-interviewee
Thiago Carvalho
boosted
Submission Deadline: 01/11/24 02:00 PM WET
"With $1,000,000 in prizes, the NIH is seeking your ideas that will help demonstrate new ways of conducting basic research, uncovering disease mechanisms, and translating knowledge into products and eventually into practice."
"A preliminary study published Monday in the journal Scientific Reports proposes a novel theory: An antioxidant found in grape skins affects how your body processes alcohol, leading to the buildup of a toxic byproduct that causes headaches."
https://www.nytimes.com/2023/11/20/well/eat/red-wine-headache.html
Thiago Carvalho
boosted
@cyrilpedia Also bringing up the problems with organ-specific microenvironments that have the power to be highly immunosuppressive: liver and brain. #Immunotherapy #organs #microenvironment
Thiago Carvalho
boosted
"When applied to a KRASG12D small molecule inhibitor I observe a wide degree of intracellular levels of the drug, and that proteomic responses largely stratify based on the concentration of drug within each single cell"
Thiago Carvalho
boosted
Thiago Carvalho
boosted
That 'select' has been the problem for the last decade
"These results suggest that programmed cell death protein 1 blockade may benefit a select group of patients with brain metastases, and support further studies to identify biomarkers and mechanisms of resistance."
#Immunology #Immunotherapy
Thiago Carvalho
boosted
"Rio de Janeiro, Brazil
People cool off at Leme beach amid a heatwave. Air temperatures surpassed 50C in some places and red warnings were issued across 3,000 cities"
Photograph: Ricardo Moraes/Reuters
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
