Thiago Carvalho @cyrilpedia@social.cleverlibre.org

In our latest interview on preprints and the future of peer review, Marcel LaFlamme (@marcellaflamme) of @PLOS spoke to us about the relationship between Review Commons and our partner journals, how peer review work deserves proper credit and a look to the future of machine-assisted peer review.

https://www.reviewcommons.org/blog/the-multiple-uses-of-peer-review-an-interview-with-marcel-laflamme/

#PeerReview #preprint #publishing

We want to make science and #PeerReview more transparent and open.
Do you want to join us?
It's easy.

When invited by platforms such as @PeerCommunityIn, @ReviewCommons, Rapid Reviews\Infectious Diseases, and @eLife agree to review #preprints

Let's improve peer review together! 💪

#research #ECR #OpenScience #preprints #publishing #PublishYourReviews

In their #JEB100 Review, @GlennaClifton @NickGravish & co discuss how rough surfaces influence animal walking and they propose terminology and a metric for characterizing the relative roughness compared with animal size to enhance comparative studies

#biomechanics #zoology #biology #sciencemastodon

https://journals.biologists.com/jeb/article/226/Suppl_1/jeb245261/307149

An important thing to keep in mind with all the talk about intranasal #Covid vaccines: this type of vaccine is tough to make. If they were easier to make, we'd have more of them.@dr_kkjetelina & @ENirenberg https://yourlocalepidemiologist.substack.com/p/hype-or-hope-nasal-covid-19-vaccines

A long & winding road.

"However, our efforts to identify a chemical inhibitor of apoptosis floundered. Whatever we tested either did not work or had only a marginal effect. We wondered whether components of the pathway might have built-in redundancies. If so, the project was dead."
#Apoptosis #CellDeath

https://www.science.org/doi/10.1126/sciadv.adi2011#.ZEmbzTtPNQI.twitter

The #RandomLaboratory model allows one to estimate whether an experimental result is likely to #replicate. This study uses new experimental data to show that such a model, when applied to archived data, improves prediction of #replicability #PLOSBiology https://plos.io/40YEv5b

“Pay for grad students hasn’t increased in 20 years, while there has been 50% inflation over the same period,” says Sarah Laframboise, a biochemistry PhD student at the University of Ottawa and executive director of Support Our Science, a student-led campaign group that is organizing the walkout.'

https://www.nature.com/articles/d41586-023-01453-8

Giant neuron derived vesicles called #exophers are processed by #phagocytosis in neighboring skin cells, and the phagocytic interaction promotes exopher production. #Neuroscience https://elifesciences.org/articles/82227?utm_source=mastodon&utm_medium=social&utm_campaign=organic

During asymmetric #CellDivision of #Drosophila male #GermlineStemCells (GSCs), #histone H3 is preferentially inherited by the GSC, while H3.3 is not; @ChenLabJHU reveals that a single amino acid (A31/S31) underlies these inheritance patterns #PLOSBiology https://plos.io/4221cXG

Harnessing anti-inflammatory potential of IDO.

Exciting new approach by @keselowsky, @GregHudalla using IDO therapeutically as an anti-inflammatory . (Short 🧵 1/5)

Suppression of local inflammation via galectin-anchored indoleamine 2,3-dioxygenase

https://www.nature.com/articles/s41551-023-01025-1

Key advance:

Generating an IDO-Gal3 fusion protein.

Gal3 binds to fly and in the extracellular matrix (ECM) of tissues, anchoring IDO in place at the site of inflammation - very clever IMHO. (2/5)

In this case, the 'in mice' tag may be a plus - getting a xenograft to take in immunocompetent hosts is a high bar.

'We report the editing of primary human islet cells to the hypoimmune HLA class I– and class II–negative and CD47-overexpressing phenotype and their reaggregation into human HIP pseudoislets (p-islets). Human HIP p-islets were shown to survive, engraft, and ameliorate diabetes in immunocompetent, allogeneic, diabetic humanized mice'

https://www.science.org/doi/10.1126/scitranslmed.adg5794?utm_campaign=SciMag&utm_source=Twitter&utm_medium=ownedSocial

Today I learned the word ‘scientist’ was coined in 1834 to describe Mary Somerville, replacing the term ‘man of science’.

#science #WomenInSTEM

https://www.themarginalian.org/2016/12/26/mary-somerville-scientist/